Vildapin
Generic Name
Vildagliptin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vildapin 50 mg tablet | ৳ 15.04 | ৳ 150.40 |
Description
Overview of the medicine
Vildapin contains Vildagliptin, an oral anti-diabetic drug used to improve glycemic control in adults with type 2 diabetes mellitus.
Uses & Indications
Dosage
Adults
50 mg once or twice daily, depending on other medications. Max 100 mg/day.
Elderly
No specific dose adjustment generally needed, but caution with renal impairment.
Renal_impairment
Moderate to severe renal impairment: 50 mg once daily.
How to Take
Oral. Can be taken with or without food.
Mechanism of Action
Vildagliptin inhibits dipeptidyl peptidase-4 (DPP-4), an enzyme that degrades incretin hormones like GLP-1 and GIP. This inhibition increases incretin levels, leading to enhanced glucose-dependent insulin secretion and reduced glucagon secretion, thus lowering blood glucose levels.
Pharmacokinetics
Onset
Glycemic effect noticeable within a few days of initiation.
Excretion
Primarily renal (approx. 85% as metabolites), small amount in feces.
Half life
Approximately 3 hours.
Absorption
Rapidly absorbed, Cmax at 1-2 hours. Bioavailability approx. 85%.
Metabolism
Hydrolysis is the major metabolic pathway, mainly by carboxylesterase 1. Not metabolized by CYP450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to vildagliptin or any component of the formulation.
- Type 1 diabetes
- Diabetic ketoacidosis
Drug Interactions
ACE inhibitors
Increased risk of angioedema.
Thiazides, corticosteroids, thyroid products, sympathomimetics
Possible reduced efficacy of vildagliptin.
Storage
Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Experience with overdose is limited. Symptomatic and supportive treatment is recommended. Vildagliptin can be removed by hemodialysis.
Pregnancy & Lactation
Not recommended during pregnancy and lactation due to insufficient data. Use only if potential benefit justifies potential risk to the fetus/infant.
Side Effects
Contraindications
- Hypersensitivity to vildagliptin or any component of the formulation.
- Type 1 diabetes
- Diabetic ketoacidosis
Drug Interactions
ACE inhibitors
Increased risk of angioedema.
Thiazides, corticosteroids, thyroid products, sympathomimetics
Possible reduced efficacy of vildagliptin.
Storage
Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Experience with overdose is limited. Symptomatic and supportive treatment is recommended. Vildagliptin can be removed by hemodialysis.
Pregnancy & Lactation
Not recommended during pregnancy and lactation due to insufficient data. Use only if potential benefit justifies potential risk to the fetus/infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., DGDA)
Patent Status
Generic versions available
Clinical Trials
Extensive clinical trials have demonstrated Vildagliptin's efficacy and safety in improving glycemic control in type 2 diabetes, both as monotherapy and in combination with other anti-diabetic agents.
Lab Monitoring
- Liver function tests (ALT/AST) before initiation and periodically during treatment.
- Renal function assessment before and during treatment.
Doctor Notes
- Monitor liver enzymes (ALT/AST) before starting treatment and at regular intervals (e.g., every 3 months for the first year, then periodically).
- Adjust dose in renal impairment.
- Counsel patients on symptoms of pancreatitis and hepatic issues.
Patient Guidelines
- Follow doctor's instructions.
- Do not stop taking without consulting a doctor.
- Maintain a healthy diet and exercise.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it's almost time for your next dose. Do not double the dose.
Driving Precautions
May cause dizziness; caution advised when driving or operating machinery, especially if combined with other medications that can cause hypoglycemia.
Lifestyle Advice
- Regular exercise
- Balanced diet
- Weight management
- Blood glucose monitoring
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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