Vildus
Generic Name
Vildagliptin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vildus 50 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Vildus 50 mg Tablet contains Vildagliptin, an oral antidiabetic drug used to treat type 2 diabetes mellitus. It helps to control blood sugar levels by improving the body's natural response to insulin. It is typically used in conjunction with diet and exercise.
Uses & Indications
Dosage
Adults
The recommended dose is 50 mg or 100 mg daily. For 50 mg tablets, it's typically 50 mg once daily or 50 mg twice daily depending on combination therapy. If used with a sulfonylurea, the dose is 50 mg once daily.
Elderly
No dose adjustment is generally required in elderly patients, but renal function should be considered.
Renal_impairment
For patients with moderate or severe renal impairment (CrCl < 50 mL/min), including ESRD on hemodialysis, the recommended dose is 50 mg once daily.
How to Take
Vildus 50 mg tablet should be taken orally, with or without food. It can be taken at any time of day but should be taken at the same time each day to maintain consistent drug levels.
Mechanism of Action
Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by inhibiting the breakdown of incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This leads to increased levels of active incretin hormones, which enhance glucose-dependent insulin secretion from pancreatic beta cells and reduce glucagon secretion from pancreatic alpha cells, thereby lowering blood glucose levels.
Pharmacokinetics
Onset
Improved glycemic control typically observed within 1-2 weeks.
Excretion
Approximately 85% of the administered dose is excreted in the urine, with a small amount (15%) excreted in feces.
Half life
Terminal elimination half-life is approximately 3 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached within 1.7 hours. Bioavailability is approximately 85%.
Metabolism
Primarily metabolized by hydrolysis (85%) via the enzyme N-dehydropyrimidinyl hydroxylase (NYH), not by CYP450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to vildagliptin or any of the excipients.
- Patients with severe heart failure (NYHA class III-IV).
- Severe hepatic impairment.
- Diabetic ketoacidosis.
Drug Interactions
ACE inhibitors
Increased risk of angioedema.
No significant interactions
Vildagliptin is not a substrate or inhibitor of CYP450 enzymes, so it has a low potential for metabolic drug interactions.
Thiazide diuretics, corticosteroids, thyroid products, sympathomimetics
May reduce the hypoglycemic effect of vildagliptin.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, symptomatic and supportive treatment should be initiated. Vildagliptin is not dialyzable.
Pregnancy & Lactation
Pregnancy Category B in some classifications, C in others. There are no adequate and well-controlled studies in pregnant women. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether vildagliptin is excreted in human milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved for treatment of Type 2 Diabetes Mellitus
Patent Status
Off-patent (Generic available)
Clinical Trials
Vildagliptin has undergone extensive clinical trials demonstrating its efficacy and safety in patients with type 2 diabetes, both as monotherapy and in combination with other antidiabetic agents. Studies like the CAROLINA and VERIFY trials have further characterized its cardiovascular safety and long-term efficacy.
Lab Monitoring
- Baseline and periodic liver enzyme monitoring (ALT, AST) especially before starting treatment, every 3 months for the first year, and periodically thereafter.
- Renal function (e.g., eGFR, creatinine) should be assessed before starting treatment and periodically thereafter.
- HbA1c levels to monitor glycemic control.
Doctor Notes
- Advise patients about the importance of diet and exercise in diabetes management.
- Counsel patients on hypoglycemia symptoms, especially when combined with sulfonylureas or insulin.
- Monitor liver function tests periodically, especially during the first year of treatment.
- Adjust dose in patients with moderate to severe renal impairment.
Patient Guidelines
- Take Vildus 50 mg tablet exactly as prescribed by your doctor.
- Do not stop taking it without consulting your doctor, even if you feel well.
- Maintain a healthy diet and regular exercise routine.
- Be aware of symptoms of hypoglycemia (low blood sugar) such as sweating, dizziness, confusion, hunger, and rapid heartbeat.
- Report any unusual symptoms, especially severe abdominal pain (possible pancreatitis) or yellowing of skin/eyes (liver problems).
Missed Dose Advice
If you miss a dose of Vildus, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Vildagliptin alone is not expected to affect the ability to drive or operate machinery. However, patients should be advised of the risk of hypoglycemia when vildagliptin is used in combination with a sulfonylurea or insulin, which could impair driving ability.
Lifestyle Advice
- Follow a balanced diet low in saturated fats and refined sugars.
- Engage in regular physical activity as advised by your doctor.
- Monitor your blood glucose levels regularly.
- Quit smoking and limit alcohol consumption.
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