Vinstin
Generic Name
Vincristine
Manufacturer
Example Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vinstin 2 mg injection | ৳ 400.00 | N/A |
Description
Overview of the medicine
Vincristine is an antineoplastic agent used in the treatment of various cancers, including leukemia, lymphoma, and some solid tumors. It works by inhibiting cell division.
Uses & Indications
Dosage
Adults
Typically 1.4 mg/m² intravenously once weekly; maximum 2 mg per dose.
Elderly
Dose adjustments may be considered due to age-related organ function decline.
Renal_impairment
No significant dose adjustment required for renal impairment, but caution advised.
How to Take
Administer intravenously only. Fatal if given intrathecally. Infuse over 1 minute or more into a running IV line.
Mechanism of Action
Vincristine acts as a mitotic inhibitor, preventing cell division by disrupting the formation of microtubules, which are essential components of the mitotic spindle.
Pharmacokinetics
Onset
Not immediate; cumulative effect over several doses.
Excretion
Mainly excreted in bile/feces; small amount in urine.
Half life
Triphasic elimination with terminal half-life of 23-85 hours.
Absorption
Poorly absorbed orally; administered intravenously.
Metabolism
Extensively metabolized by the liver, primarily via CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to vincristine or other vinca alkaloids
- Patients with demyelinating Charcot-Marie-Tooth syndrome
- Intrathecal administration (fatal)
Drug Interactions
Phenytoin
May decrease phenytoin levels.
CYP3A4 inhibitors (e.g., azole antifungals, macrolides)
May increase vincristine levels and toxicity.
Storage
Store refrigerated between 2°C to 8°C (36°F to 46°F). Protect from light.
Overdose
Overdose leads to exaggerated side effects, particularly neurotoxicity. No specific antidote; symptomatic and supportive care.
Pregnancy & Lactation
Category D. Contraindicated during pregnancy due to potential fetal harm. Avoid breastfeeding as drug may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to vincristine or other vinca alkaloids
- Patients with demyelinating Charcot-Marie-Tooth syndrome
- Intrathecal administration (fatal)
Drug Interactions
Phenytoin
May decrease phenytoin levels.
CYP3A4 inhibitors (e.g., azole antifungals, macrolides)
May increase vincristine levels and toxicity.
Storage
Store refrigerated between 2°C to 8°C (36°F to 46°F). Protect from light.
Overdose
Overdose leads to exaggerated side effects, particularly neurotoxicity. No specific antidote; symptomatic and supportive care.
Pregnancy & Lactation
Category D. Contraindicated during pregnancy due to potential fetal harm. Avoid breastfeeding as drug may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months when stored as recommended.
Availability
Hospitals, specialized cancer centers
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Vincristine has been extensively studied in numerous clinical trials for various cancers, often as part of multi-drug regimens.
Lab Monitoring
- Complete blood count (CBC)
- Liver function tests (LFTs)
- Renal function tests
- Neurological assessment
Doctor Notes
- Strictly for IV use only; verify administration route carefully.
- Monitor for neurological symptoms and bowel function regularly.
- Dose reduction or delay may be necessary for significant neurotoxicity.
Patient Guidelines
- Report any numbness, tingling, or pain in hands/feet immediately.
- Maintain good hydration to prevent constipation.
- Avoid accidental exposure to the drug.
Missed Dose Advice
Contact your doctor or oncology team immediately if a dose is missed. Do not double the dose.
Driving Precautions
May cause neurological side effects (e.g., blurred vision, peripheral neuropathy) that could impair ability to drive or operate machinery. Exercise caution.
Lifestyle Advice
- Balanced diet and exercise as tolerated.
- Consult doctor about any herbal supplements.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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