Visovit
Generic Name
Visovit 60 mg Capsule
Manufacturer
ACI Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| visovit 60 mg capsule | ৳ 10.00 | ৳ 60.00 |
Description
Overview of the medicine
Visovit 60 mg Capsule contains Tocopheryl Acetate, a form of Vitamin E. It is an essential fat-soluble vitamin known for its potent antioxidant properties, protecting cells from damage caused by free radicals. It plays a crucial role in maintaining immune function, skin health, eye health, and red blood cell formation.
Uses & Indications
Dosage
Adults
For general health and antioxidant support, typically 1-2 capsules (60-120 mg) daily, or as advised by a physician. For specific deficiency states, higher doses may be prescribed based on severity.
Elderly
No specific dosage adjustment is generally required for elderly patients; standard adult doses are usually well-tolerated. However, it is advisable to consult a physician.
Renal_impairment
No specific dose adjustment for Vitamin E is generally needed in patients with renal impairment, but medical consultation is recommended.
How to Take
Take the Visovit 60 mg capsule orally with a glass of water. As Vitamin E is a fat-soluble vitamin, it is best absorbed when taken with a meal containing some fat.
Mechanism of Action
Vitamin E (Tocopherol) acts primarily as a lipid-soluble antioxidant. It incorporates into cell membranes and lipoproteins, where it neutralizes free radicals by donating a hydrogen atom from its phenolic hydroxyl group, preventing the oxidation of polyunsaturated fatty acids. This protection against oxidative stress helps maintain cellular integrity and function, supports immune responses, and contributes to proper functioning of various physiological systems.
Pharmacokinetics
Onset
Therapeutic effects (e.g., antioxidant protection) are gradual and accumulate over time with regular intake, rather than an acute onset.
Excretion
Excreted primarily through the bile into the feces, with a smaller portion excreted via the urine as glucuronides and other metabolites.
Half life
The plasma half-life of alpha-tocopherol is approximately 48 hours for short-term administration, but it can be considerably longer (days to weeks) with chronic supplementation due to its storage in adipose tissues.
Absorption
Absorbed from the gastrointestinal tract, primarily in the jejunum, requiring the presence of bile salts, pancreatic lipase, and dietary fat for efficient absorption. Bioavailability can vary significantly depending on the food matrix and individual factors.
Metabolism
Metabolized in the liver by cytochrome P450 enzymes (primarily CYP3A4) into various polar metabolites, including carboxyethyl hydroxychromans, which are then conjugated.
Side Effects
Contraindications
- Hypersensitivity to Tocopheryl Acetate or any other component of the capsule.
- Caution in patients on anticoagulant therapy or with bleeding disorders, especially with high doses of Vitamin E (generally >400 IU/day).
Drug Interactions
Anticoagulants (e.g., Warfarin)
High doses of Vitamin E (typically >400 IU/day) may potentiate the effects of anticoagulants, increasing the risk of bleeding or bruising. Monitor INR/PT closely.
Statins (e.g., Simvastatin, Atorvastatin)
Some evidence suggests that high doses of Vitamin E in combination with other antioxidants (e.g., Vitamin C, beta-carotene, selenium) might interfere with the cholesterol-lowering effects of statins, though findings are conflicting and require further study.
Antiplatelet drugs (e.g., Aspirin, Clopidogrel)
May increase the risk of bleeding when taken concurrently with high doses of Vitamin E.
Fat-soluble vitamin absorption inhibitors (e.g., Cholestyramine, Colestipol, Orlistat, Mineral Oil)
These agents can reduce the absorption of Vitamin E. Administer Vitamin E at least 2 hours before or after these medications.
Storage
Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Acute overdose with Vitamin E is rare and generally not life-threatening. Chronic intake of very high doses (e.g., >1000 mg/day or >1500 IU/day) over extended periods may lead to increased bleeding risk, especially in susceptible individuals, and can cause symptoms like headache, fatigue, nausea, diarrhea, abdominal cramps, and blurred vision. Management involves discontinuation of the supplement and symptomatic supportive care.
Pregnancy & Lactation
Vitamin E is generally considered safe at recommended daily allowances during pregnancy and lactation. However, high doses (above the upper limit of 1000 mg or 1500 IU per day) should be avoided unless specifically prescribed and monitored by a healthcare professional, due to insufficient data on safety at very high levels.
Side Effects
Contraindications
- Hypersensitivity to Tocopheryl Acetate or any other component of the capsule.
- Caution in patients on anticoagulant therapy or with bleeding disorders, especially with high doses of Vitamin E (generally >400 IU/day).
Drug Interactions
Anticoagulants (e.g., Warfarin)
High doses of Vitamin E (typically >400 IU/day) may potentiate the effects of anticoagulants, increasing the risk of bleeding or bruising. Monitor INR/PT closely.
Statins (e.g., Simvastatin, Atorvastatin)
Some evidence suggests that high doses of Vitamin E in combination with other antioxidants (e.g., Vitamin C, beta-carotene, selenium) might interfere with the cholesterol-lowering effects of statins, though findings are conflicting and require further study.
Antiplatelet drugs (e.g., Aspirin, Clopidogrel)
May increase the risk of bleeding when taken concurrently with high doses of Vitamin E.
Fat-soluble vitamin absorption inhibitors (e.g., Cholestyramine, Colestipol, Orlistat, Mineral Oil)
These agents can reduce the absorption of Vitamin E. Administer Vitamin E at least 2 hours before or after these medications.
Storage
Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Acute overdose with Vitamin E is rare and generally not life-threatening. Chronic intake of very high doses (e.g., >1000 mg/day or >1500 IU/day) over extended periods may lead to increased bleeding risk, especially in susceptible individuals, and can cause symptoms like headache, fatigue, nausea, diarrhea, abdominal cramps, and blurred vision. Management involves discontinuation of the supplement and symptomatic supportive care.
Pregnancy & Lactation
Vitamin E is generally considered safe at recommended daily allowances during pregnancy and lactation. However, high doses (above the upper limit of 1000 mg or 1500 IU per day) should be avoided unless specifically prescribed and monitored by a healthcare professional, due to insufficient data on safety at very high levels.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Generally 24 to 36 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, supermarkets, online stores
Approval Status
Approved by health authorities (e.g., DGDA)
Patent Status
Generic, patent expired
Clinical Trials
Numerous clinical trials have investigated Vitamin E's role in various conditions, including cardiovascular disease, cancer prevention, and neurodegenerative disorders. While it functions as a powerful antioxidant in vitro and in animal models, large-scale human trials have yielded mixed and sometimes contradictory results regarding its effectiveness for preventing chronic diseases, particularly at high doses. Some studies have even suggested potential harms in specific populations. Ongoing research continues to explore optimal dosing, specific tocopherol forms, and target populations.
Lab Monitoring
- For patients on anticoagulant therapy receiving high doses of Vitamin E, regular monitoring of INR/PT is recommended to assess bleeding risk.
- Serum Vitamin E levels may be monitored in cases of suspected severe deficiency or toxicity.
Doctor Notes
- Emphasize the importance of patient education regarding the potential for increased bleeding risk when high doses of Vitamin E are combined with anticoagulants or antiplatelet agents.
- Advise patients that while Vitamin E is an antioxidant, current evidence does not support widespread high-dose supplementation for chronic disease prevention in healthy individuals.
- Counsel on obtaining Vitamin E primarily through a balanced diet.
- Monitor INR/PT in relevant patients.
Patient Guidelines
- Take Visovit 60 mg capsule exactly as directed by your healthcare provider or as per packaging instructions.
- Do not exceed the recommended daily dose without consulting a doctor.
- Inform your doctor or pharmacist about all other medications, herbal supplements, and vitamins you are taking to avoid potential interactions.
- Store the capsules in a cool, dry place, away from direct sunlight and moisture, and out of reach of children.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Visovit 60 mg capsule is generally not known to affect the ability to drive or operate machinery. However, if you experience any side effects such as blurred vision, dizziness, or fatigue, avoid driving or engaging in activities that require alertness until you feel well.
Lifestyle Advice
- Incorporate a balanced diet rich in Vitamin E sources such as vegetable oils (wheat germ, sunflower), nuts (almonds, hazelnuts), seeds (sunflower seeds), and green leafy vegetables (spinach, broccoli).
- Maintain a healthy lifestyle with regular physical activity and avoidance of smoking, as smoking can deplete vitamin E levels.
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