Vita-Heart
Generic Name
Metoprolol Tartrate
Manufacturer
Medix Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vita heart 25 mg tablet | ৳ 3.00 | N/A |
Description
Overview of the medicine
Vita-Heart 25 mg tablet contains Metoprolol Tartrate, a beta-blocker used to treat high blood pressure, angina, and certain heart rhythm disorders. It works by blocking the action of natural chemicals in your body, like epinephrine, on the heart and blood vessels.
Uses & Indications
Dosage
Adults
Hypertension: Initially 50-100 mg daily in single or divided doses. Angina: 50-100 mg daily in divided doses. Myocardial Infarction: 50 mg twice daily. The dose can be adjusted based on patient response and tolerability, up to a maximum of 400 mg/day.
Elderly
No specific dose adjustment is generally required, but monitor carefully for adverse effects, starting with lower doses.
Renal_impairment
No dose adjustment is usually needed for patients with renal impairment, as metoprolol is primarily metabolized in the liver.
How to Take
Take Vita-Heart tablet orally with or without food, usually once or twice daily as directed by your doctor. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Metoprolol is a selective beta-1 adrenoceptor blocking agent. It competitively blocks beta-1 receptors, primarily located in the heart, leading to decreased heart rate, reduced myocardial contractility, and lower blood pressure. It also inhibits renin release from the kidneys.
Pharmacokinetics
Onset
Within 1 hour for blood pressure reduction, peak effect within 1-2 hours.
Excretion
Excreted mainly by the kidneys (approx. 95%), with only a small portion as unchanged drug.
Half life
3-7 hours (elimination half-life).
Absorption
Rapid and complete absorption from the GI tract (approx. 90%), but undergoes significant first-pass metabolism, resulting in a systemic bioavailability of about 50%.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6, into inactive metabolites.
Side Effects
Contraindications
- Severe bradycardia (very slow heart rate)
- Second- or third-degree heart block
- Cardiogenic shock
- Decompensated heart failure
- Sick sinus syndrome (unless a pacemaker is in place)
- Severe peripheral arterial disease
Drug Interactions
Digoxin
Increased risk of bradycardia.
Insulin and oral antidiabetics
Beta-blockers may mask symptoms of hypoglycemia and potentiate hypoglycemic effects.
NSAIDs (e.g., ibuprofen, indomethacin)
May reduce the antihypertensive effects of metoprolol.
Fluoxetine, Paroxetine, Bupropion, Quinidine
May inhibit metoprolol metabolism, leading to increased plasma levels.
Calcium Channel Blockers (e.g., verapamil, diltiazem)
Increased risk of bradycardia, AV block, and heart failure.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe bradycardia, hypotension, bronchospasm, and cardiac arrest. Treatment involves supportive measures, including atropine for bradycardia, vasopressors for hypotension, and bronchodilators for bronchospasm. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Metoprolol is excreted in breast milk; caution should be exercised when administered to a nursing mother. Consult your doctor.
Side Effects
Contraindications
- Severe bradycardia (very slow heart rate)
- Second- or third-degree heart block
- Cardiogenic shock
- Decompensated heart failure
- Sick sinus syndrome (unless a pacemaker is in place)
- Severe peripheral arterial disease
Drug Interactions
Digoxin
Increased risk of bradycardia.
Insulin and oral antidiabetics
Beta-blockers may mask symptoms of hypoglycemia and potentiate hypoglycemic effects.
NSAIDs (e.g., ibuprofen, indomethacin)
May reduce the antihypertensive effects of metoprolol.
Fluoxetine, Paroxetine, Bupropion, Quinidine
May inhibit metoprolol metabolism, leading to increased plasma levels.
Calcium Channel Blockers (e.g., verapamil, diltiazem)
Increased risk of bradycardia, AV block, and heart failure.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe bradycardia, hypotension, bronchospasm, and cardiac arrest. Treatment involves supportive measures, including atropine for bradycardia, vasopressors for hypotension, and bronchodilators for bronchospasm. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Metoprolol is excreted in breast milk; caution should be exercised when administered to a nursing mother. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials for hypertension, angina, and post-myocardial infarction. Demonstrated efficacy in reducing cardiovascular events and mortality.
Lab Monitoring
- Blood pressure monitoring
- Heart rate monitoring
- Renal function (e.g., creatinine, BUN) in patients with pre-existing renal impairment
- Blood glucose monitoring in diabetic patients
Doctor Notes
- Counsel patients on importance of gradual withdrawal.
- Monitor heart rate and blood pressure regularly.
- Caution in patients with asthma/COPD due to potential for bronchospasm.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor.
- Take your medicine regularly at the same time each day to get the most benefit.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or fatigue, especially at the start of treatment or when the dose is increased. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as advised by your doctor.
- Avoid smoking and limit alcohol consumption.
- Manage stress effectively.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.