Vitacare
Generic Name
Pyridoxine Hydrochloride (Vitamin B6)
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vitacare 5 mg syrup | ৳ 20.00 | N/A |
Description
Overview of the medicine
Vitacare 5 mg Syrup contains Pyridoxine Hydrochloride, commonly known as Vitamin B6. It is an essential water-soluble vitamin involved in numerous bodily functions including metabolism, nerve function, and red blood cell formation. This syrup is primarily used to prevent and treat Vitamin B6 deficiency.
Uses & Indications
Dosage
Adults
Typical dosage for deficiency: 5-25 mg daily. For Isoniazid prophylaxis: 10 mg daily. For treatment of Isoniazid toxicity: 50-200 mg daily in divided doses.
Elderly
Same as adult dosage; monitor for renal function, though specific adjustment is usually not required for moderate impairment.
Renal_impairment
No specific dose adjustment is typically needed for moderate renal impairment. For severe impairment, consultation with a physician is advised.
How to Take
Take orally, with or without food. Measure the liquid dose accurately using the provided measuring spoon or cup. Shake the bottle well before each use.
Mechanism of Action
Pyridoxine, in its active form pyridoxal 5'-phosphate (PLP), acts as a coenzyme for a wide variety of metabolic enzymes. It is crucial for amino acid, carbohydrate, and fat metabolism, neurotransmitter synthesis (e.g., serotonin, dopamine), and hemoglobin formation.
Pharmacokinetics
Onset
Varies depending on deficiency severity and individual metabolism; symptom improvement may be observed within days to weeks.
Excretion
Excreted renally as 4-pyridoxic acid, the major inactive metabolite, and other forms.
Half life
The elimination half-life of pyridoxal 5'-phosphate is approximately 15-20 days.
Absorption
Readily absorbed from the gastrointestinal tract, primarily in the jejunum. Peak plasma concentrations are typically reached within 1-2 hours.
Metabolism
Metabolized primarily in the liver to its active form, pyridoxal 5'-phosphate (PLP), and other metabolites.
Side Effects
Contraindications
- Hypersensitivity to pyridoxine or any component of the formulation.
- Patients undergoing levodopa therapy without a concomitant carbidopa inhibitor.
Drug Interactions
Levodopa
Pyridoxine can decrease the effectiveness of levodopa (without carbidopa) by enhancing its peripheral metabolism. This interaction is reduced or eliminated when carbidopa is co-administered.
Phenobarbital, Phenytoin
High doses of pyridoxine may lower serum concentrations of these anticonvulsants, potentially reducing their efficacy.
Isoniazid, Penicillamine, Hydralazine, Cycloserine
These drugs are pyridoxine antagonists and can increase the requirement for pyridoxine, potentially leading to deficiency. Supplementation may be necessary.
Storage
Store below 30°C in a dry place, protected from light. Keep the bottle tightly closed. Do not freeze.
Overdose
Acute overdose with pyridoxine is rare due to its water-soluble nature. Chronic overdose (e.g., >200 mg/day for prolonged periods) can lead to severe peripheral sensory neuropathy, ataxia, and skin lesions. Management involves discontinuing the drug and providing symptomatic and supportive care.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended daily allowances. However, high doses beyond standard supplementation should be avoided unless medically advised.
Side Effects
Contraindications
- Hypersensitivity to pyridoxine or any component of the formulation.
- Patients undergoing levodopa therapy without a concomitant carbidopa inhibitor.
Drug Interactions
Levodopa
Pyridoxine can decrease the effectiveness of levodopa (without carbidopa) by enhancing its peripheral metabolism. This interaction is reduced or eliminated when carbidopa is co-administered.
Phenobarbital, Phenytoin
High doses of pyridoxine may lower serum concentrations of these anticonvulsants, potentially reducing their efficacy.
Isoniazid, Penicillamine, Hydralazine, Cycloserine
These drugs are pyridoxine antagonists and can increase the requirement for pyridoxine, potentially leading to deficiency. Supplementation may be necessary.
Storage
Store below 30°C in a dry place, protected from light. Keep the bottle tightly closed. Do not freeze.
Overdose
Acute overdose with pyridoxine is rare due to its water-soluble nature. Chronic overdose (e.g., >200 mg/day for prolonged periods) can lead to severe peripheral sensory neuropathy, ataxia, and skin lesions. Management involves discontinuing the drug and providing symptomatic and supportive care.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended daily allowances. However, high doses beyond standard supplementation should be avoided unless medically advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Approved by DGDA, FDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials and observational studies have demonstrated the efficacy and safety of pyridoxine in preventing and treating Vitamin B6 deficiency and related conditions across various patient populations.
Lab Monitoring
- Plasma pyridoxal 5'-phosphate (PLP) levels (to assess Vitamin B6 status)
- Nerve conduction studies (if symptoms of neuropathy develop, especially with high doses)
- Complete blood count (in cases of sideroblastic anemia)
Doctor Notes
- Advise patients regarding the interaction with levodopa (without carbidopa) and potential reduction in anticonvulsant efficacy at high doses.
- Educate patients on symptoms of peripheral neuropathy and to report them if high doses are prescribed for prolonged periods.
- Regularly assess Vitamin B6 status in patients at risk of deficiency, especially those on antagonist medications like isoniazid.
Patient Guidelines
- Do not exceed the recommended dose without consulting a healthcare professional.
- If you experience any unusual side effects, contact your doctor immediately.
- Store the medicine as directed and keep it out of reach of children.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once to make up for a missed one.
Driving Precautions
Generally, Vitacare 5 mg Syrup does not impair the ability to drive or operate machinery. However, if you experience dizziness or drowsiness, it is advisable to avoid such activities until you are certain you can perform them safely.
Lifestyle Advice
- Maintain a balanced diet rich in B vitamins (e.g., meat, fish, whole grains, nuts, fruits, vegetables).
- Avoid excessive alcohol consumption, as it can interfere with B vitamin absorption and metabolism.
- Consult your doctor or a nutritionist for personalized dietary advice.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.