Vitalgin

Oral, with or without food.

Paracetamol works by inhibiting prostaglandin synthesis in the central nervous system, leading to analgesic and antipyretic effects. Orphenadrine Citrate is a centrally acting skeletal muscle relaxant whose mechanism of action is not fully understood but is thought to involve inhibition of muscle spasm through its action on the reticular formation in the brainstem and spinal cord. It also has anticholinergic properties.

• Hypersensitivity to Paracetamol or Orphenadrine
• Glaucoma
• Myasthenia gravis
• Prostatic hypertrophy or bladder neck obstruction
• Pyloric or duodenal obstruction
• Oesophageal spasm
• Cardiospasm (megaesophagus)
• Children under 12 years
• Severe hepatic or renal impairment

Store below 30°C, protected from light and moisture. Keep out of reach of children.

Paracetamol overdose can cause hepatic necrosis (symptoms: nausea, vomiting, abdominal pain, jaundice). Antidote: N-acetylcysteine. Orphenadrine overdose symptoms include anticholinergic effects (dry mouth, blurred vision, tachycardia, urinary retention, hallucinations, seizures, coma). Treatment: Symptomatic and supportive, physostigmine might be used for severe anticholinergic symptoms.

Pregnancy Category B/C for Orphenadrine (caution advised). Paracetamol is generally considered safe in pregnancy at therapeutic doses. This combination should be used during pregnancy or lactation only if clearly needed and the potential benefits outweigh the risks. Orphenadrine may be excreted in breast milk; avoid during lactation if possible.