Thiamine 100 mg Injection
Generic Name
Thiamine Hydrochloride 100 mg Injection
Manufacturer
Various generic manufacturers
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vitamin b1 100 mg injection | ৳ 3.50 | N/A |
Description
Overview of the medicine
Thiamine (Vitamin B1) 100 mg injection is used to treat or prevent thiamine deficiency, which can lead to conditions like beriberi and Wernicke-Korsakoff syndrome. It is essential for carbohydrate metabolism and proper nerve, muscle, and heart function.
Uses & Indications
Dosage
Adults
For severe deficiency or Wernicke's encephalopathy: 100 mg IM or slow IV daily for several days, then 50-100 mg IM daily until adequate diet. For prophylaxis: 50-100 mg IM or IV once daily.
Elderly
Similar to adults, but renal function should be considered for dosage adjustment.
Renal_impairment
No specific dose adjustment is usually required, as excess is excreted, but caution is advised in severe cases.
How to Take
Administer by deep intramuscular (IM) injection or by slow intravenous (IV) injection. IV administration should be slow (over 5-10 minutes) to avoid potential adverse reactions.
Mechanism of Action
Thiamine is converted in the body to thiamine pyrophosphate (TPP), which acts as a coenzyme in several metabolic pathways, particularly in carbohydrate metabolism. It is crucial for the decarboxylation of alpha-keto acids, such as pyruvate and alpha-ketoglutarate, which are vital for energy production.
Pharmacokinetics
Onset
Rapid, within minutes for IV administration.
Excretion
Excreted renally as metabolites and unchanged thiamine.
Half life
Approximately 96 minutes.
Absorption
Rapidly and completely absorbed following intramuscular (IM) administration.
Metabolism
Primarily metabolized in the liver to various metabolites.
Side Effects
Contraindications
- Hypersensitivity to thiamine or any component of the formulation.
Drug Interactions
Neuromuscular blockers
May potentiate the action of neuromuscular blockers.
Sulfite-containing solutions
Sulfites can inactivate thiamine. Avoid mixing with sulfite-containing solutions.
Storage
Store below 25-30°C. Protect from light. Do not freeze.
Overdose
Acute overdose is rare and generally not associated with severe toxicity due to the water-soluble nature of thiamine and its rapid renal excretion. Symptoms might include mild gastrointestinal upset or mild allergic reactions.
Pregnancy & Lactation
Thiamine is an essential vitamin and generally considered safe during pregnancy and lactation at recommended daily allowances. Higher doses should only be used if clearly needed and prescribed by a healthcare professional.
Side Effects
Contraindications
- Hypersensitivity to thiamine or any component of the formulation.
Drug Interactions
Neuromuscular blockers
May potentiate the action of neuromuscular blockers.
Sulfite-containing solutions
Sulfites can inactivate thiamine. Avoid mixing with sulfite-containing solutions.
Storage
Store below 25-30°C. Protect from light. Do not freeze.
Overdose
Acute overdose is rare and generally not associated with severe toxicity due to the water-soluble nature of thiamine and its rapid renal excretion. Symptoms might include mild gastrointestinal upset or mild allergic reactions.
Pregnancy & Lactation
Thiamine is an essential vitamin and generally considered safe during pregnancy and lactation at recommended daily allowances. Higher doses should only be used if clearly needed and prescribed by a healthcare professional.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to packaging for specific expiry date.
Availability
Available in hospitals, pharmacies, and clinics
Approval Status
Approved by major regulatory bodies globally
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Thiamine has been extensively studied for its role in preventing and treating deficiency syndromes, particularly in alcoholic patients. Ongoing research explores its broader neuroprotective potential.
Lab Monitoring
- Monitoring of thiamine levels may be done in cases of severe deficiency or malabsorption syndromes.
Doctor Notes
- In suspected Wernicke's encephalopathy, administer thiamine before or concurrently with glucose administration to prevent precipitation of Wernicke's.
- Always assess for potential allergic reactions, especially with IV administration.
Patient Guidelines
- Follow your doctor's instructions for dose and administration.
- Report any unusual or severe side effects immediately.
- If receiving for Wernicke's encephalopathy, ensure adequate follow-up.
Missed Dose Advice
If you miss a dose, administer it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Thiamine injection is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in thiamine (e.g., whole grains, legumes, meat).
- If deficiency is due to alcoholism, seek help for alcohol cessation.
- Avoid excessive alcohol consumption as it can deplete thiamine stores.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.