Vitex-M
Generic Name
Vitex agnus-castus Extract + Magnesium
Manufacturer
Popular Pharmaceutical Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vitex m tablet | ৳ 1.50 | N/A |
Description
Overview of the medicine
A herbal and mineral supplement used to support women's health, particularly for managing symptoms associated with Premenstrual Syndrome (PMS), menstrual cycle irregularities, and menopausal discomforts.
Uses & Indications
Dosage
Adults
Typically 1-2 tablets once daily, or as directed by a healthcare professional. Best taken in the morning.
Elderly
Same as adult dosage, but caution is advised; consult a healthcare professional.
Renal_impairment
Use with caution due to Magnesium content; consult a healthcare professional. Dosage adjustment may be necessary for severe impairment.
How to Take
Oral. Take with water, preferably in the morning.
Mechanism of Action
Vitex agnus-castus is believed to act on the pituitary gland, affecting the release of luteinizing hormone (LH) and subsequently modulating prolactin levels, which may help balance other hormones like estrogen and progesterone. Magnesium contributes to muscle and nerve function, blood glucose control, and bone health, and may help alleviate PMS symptoms like cramps and mood swings.
Pharmacokinetics
Onset
Effects may be noticed after several weeks of consistent use (typically 1-3 months for Vitex).
Excretion
Excretion of Vitex agnus-castus metabolites is primarily renal. Magnesium is primarily excreted via the kidneys.
Half life
Specific half-life for all active compounds of Vitex agnus-castus is not well-established. Magnesium half-life varies depending on physiological state.
Absorption
Vitex agnus-castus compounds are generally absorbed orally. Magnesium is absorbed in the small intestine.
Metabolism
Metabolism of Vitex agnus-castus compounds likely involves liver enzymes. Magnesium is not metabolized but utilized in various bodily functions.
Side Effects
Contraindications
- Pregnancy (due to potential hormonal effects)
- Lactation (insufficient data)
- Known hypersensitivity to Vitex agnus-castus or Magnesium
- Hormone-sensitive cancers (e.g., breast cancer)
- Patients taking dopamine agonists/antagonists or hormone therapy
Drug Interactions
Anticoagulants/Antiplatelets
Magnesium might have mild anticoagulant effects, theoretically increasing bleeding risk with these drugs.
Dopamine agonists/antagonists
Vitex may have dopaminergic effects, potentially interacting with medications affecting dopamine levels.
Antibiotics (Tetracyclines, Fluoroquinolones)
Magnesium can chelate certain antibiotics, reducing their absorption. Take at least 2-4 hours apart.
Hormone Replacement Therapy (HRT) or oral contraceptives
May interfere with the effectiveness of hormonal medications due to Vitex's hormonal modulating effects.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of Vitex agnus-castus overdose are generally mild (e.g., stomach upset). High doses of Magnesium can cause diarrhea, nausea, vomiting, lethargy, muscle weakness, and in severe cases, respiratory depression and cardiac arrest. Management is supportive, including discontinuing the product, hydration, and monitoring of vital signs. Severe magnesium toxicity may require intravenous calcium gluconate.
Pregnancy & Lactation
Contraindicated during pregnancy due to potential hormonal effects. Consult a doctor during lactation, as insufficient data exists on its safety for nursing infants.
Side Effects
Contraindications
- Pregnancy (due to potential hormonal effects)
- Lactation (insufficient data)
- Known hypersensitivity to Vitex agnus-castus or Magnesium
- Hormone-sensitive cancers (e.g., breast cancer)
- Patients taking dopamine agonists/antagonists or hormone therapy
Drug Interactions
Anticoagulants/Antiplatelets
Magnesium might have mild anticoagulant effects, theoretically increasing bleeding risk with these drugs.
Dopamine agonists/antagonists
Vitex may have dopaminergic effects, potentially interacting with medications affecting dopamine levels.
Antibiotics (Tetracyclines, Fluoroquinolones)
Magnesium can chelate certain antibiotics, reducing their absorption. Take at least 2-4 hours apart.
Hormone Replacement Therapy (HRT) or oral contraceptives
May interfere with the effectiveness of hormonal medications due to Vitex's hormonal modulating effects.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of Vitex agnus-castus overdose are generally mild (e.g., stomach upset). High doses of Magnesium can cause diarrhea, nausea, vomiting, lethargy, muscle weakness, and in severe cases, respiratory depression and cardiac arrest. Management is supportive, including discontinuing the product, hydration, and monitoring of vital signs. Severe magnesium toxicity may require intravenous calcium gluconate.
Pregnancy & Lactation
Contraindicated during pregnancy due to potential hormonal effects. Consult a doctor during lactation, as insufficient data exists on its safety for nursing infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, health stores
Approval Status
Marketed as a dietary supplement/herbal medicine
Patent Status
Ingredients are generally off-patent
Clinical Trials
Numerous studies support the use of Vitex agnus-castus for PMS and menstrual irregularities. Magnesium's efficacy is also well-documented for various conditions including muscle cramps and mood.
Lab Monitoring
- No specific routine lab monitoring required for typical use.
- For long-term use, especially in individuals with kidney issues, magnesium levels might be monitored.
Doctor Notes
- Advise patients on the importance of consistent use for desired effects.
- Counsel on potential interactions with hormonal therapies.
- Monitor for symptom improvement and any adverse effects.
Patient Guidelines
- Take consistently for best results, as effects may not be immediate.
- Inform your doctor about all supplements and medications you are taking.
- Do not exceed the recommended dose.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
Generally considered safe. However, if you experience dizziness or fatigue, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet and regular exercise.
- Manage stress through relaxation techniques.
- Avoid excessive caffeine and alcohol.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.