Vitilimus
Generic Name
vitilimus-01-ointment
Manufacturer
Global Pharma Inc.
Country
USA
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vitilimus 01 ointment | ৳ 1,000.00 | N/A |
Description
Overview of the medicine
Vitilimus-01-Ointment is a topical immunomodulator used for the treatment of certain inflammatory skin conditions, primarily characterized by its ability to modulate the immune response in the skin.
Uses & Indications
Dosage
Adults
Apply a thin layer to affected skin twice daily. Continue for up to 6 weeks, then reassess.
Elderly
No specific dosage adjustment required; use with caution.
Renal_impairment
No specific dosage adjustment required as systemic absorption is minimal.
How to Take
For external use only. Apply a thin layer to the affected skin area and gently rub in completely. Wash hands thoroughly after application.
Mechanism of Action
Vitilimus-01-Ointment is believed to act as a calcineurin inhibitor, preventing T-cell activation and the release of inflammatory cytokines. This leads to a reduction in inflammation and itching in the affected skin.
Pharmacokinetics
Onset
Clinical improvement typically observed within 1-2 weeks.
Excretion
Mainly via feces for systemically absorbed drug; negligible renal excretion.
Half life
Not precisely determined for topical application; systemic half-life expected to be variable and long.
Absorption
Minimal systemic absorption through intact skin; increased absorption with compromised skin barrier.
Metabolism
Primarily hepatic via CYP3A4 for systemically absorbed drug.
Side Effects
Contraindications
- Hypersensitivity to vitilimus or any component of the ointment
- Netherton's Syndrome or other skin conditions that might increase systemic absorption
- Immunocompromised patients
Drug Interactions
Live attenuated vaccines
Theoretical risk of reduced efficacy if systemic absorption occurs, but generally not an issue with topical use.
Other topical immunosuppressants
Concurrent use not recommended due to potential for additive immunosuppression and increased systemic exposure.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause systemic toxicity due to limited absorption. If accidentally ingested, seek medical advice immediately. Symptoms may include nausea, vomiting, abdominal pain.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Exercise caution when administered to a nursing woman, as it is unknown if vitilimus is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities
Patent Status
Patent protected
Clinical Trials
Phase III clinical trials demonstrated significant improvement in eczema area and severity index (EASI) scores compared to placebo in patients with moderate to severe atopic dermatitis.
Lab Monitoring
- Not generally required for topical use. Monitor for signs of skin infection or systemic adverse effects if extensive application or compromised skin barrier.
Doctor Notes
- Counsel patients on potential skin cancer risk and importance of sun protection.
- Emphasize proper application technique and avoidance of mucous membranes.
- Regularly assess patient's condition and need for continued therapy.
Patient Guidelines
- Apply only to affected areas.
- Avoid contact with eyes, mouth, and mucous membranes.
- Do not cover treated areas with occlusive dressings unless directed by a doctor.
- Limit sun exposure and use sunscreen.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not apply extra ointment to make up for a missed dose.
Driving Precautions
No known effects on ability to drive or operate machinery, as it is a topical preparation with minimal systemic absorption.
Lifestyle Advice
- Maintain good skin hygiene.
- Avoid known irritants or allergens.
- Keep skin moisturized to reduce dryness.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.