Vitrocin
Generic Name
Doxycycline Hyclate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vitrocin 100 mg capsule | ৳ 2.00 | ৳ 20.00 |
Description
Overview of the medicine
Vitrocin 100 mg Capsule contains Doxycycline Hyclate, a broad-spectrum tetracycline antibiotic. It is used to treat a wide variety of bacterial infections.
Uses & Indications
Dosage
Adults
Typical dosage is 100 mg once or twice daily, depending on the infection. For severe infections, 100 mg every 12 hours.
Elderly
No specific dose adjustment required for elderly patients based on renal function, but caution is advised with hepatic impairment.
Renal_impairment
No dosage adjustment needed in renal impairment due to primary excretion via feces.
How to Take
Take orally with a full glass of water, either with food or milk to minimize esophageal irritation. Avoid lying down for at least 30 minutes to 1 hour after taking.
Mechanism of Action
Doxycycline inhibits bacterial protein synthesis by reversibly binding to the 30S ribosomal subunit, preventing the attachment of aminoacyl-tRNA to the ribosomal acceptor site. This leads to bacteriostatic effects.
Pharmacokinetics
Onset
Within 1-2 hours.
Excretion
Primarily excreted in feces (about 30-60%) and urine (about 40%).
Half life
Approximately 16-24 hours.
Absorption
Well absorbed orally, approximately 90-100%. Food and milk products slightly decrease absorption.
Metabolism
Not extensively metabolized; some hepatic metabolism occurs.
Side Effects
Contraindications
- Known hypersensitivity to doxycycline or other tetracyclines
- Children under 8 years of age (due to potential for permanent tooth discoloration and bone growth inhibition)
- Severe hepatic impairment
Drug Interactions
Penicillins
May interfere with the bactericidal action of penicillins.
Oral contraceptives
May reduce efficacy of oral contraceptives. Advise alternative contraception.
Anticoagulants (e.g., Warfarin)
May potentiate anticoagulant effect. Monitor INR.
Antacids, iron supplements, calcium supplements
Decrease doxycycline absorption. Separate administration by at least 2-3 hours.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, and diarrhea. Management is symptomatic and supportive, including gastric lavage or activated charcoal if recent ingestion.
Pregnancy & Lactation
Pregnancy Category D. Doxycycline crosses the placenta and can cause permanent tooth discoloration and bone growth inhibition in the fetus. Avoid during pregnancy and lactation.
Side Effects
Contraindications
- Known hypersensitivity to doxycycline or other tetracyclines
- Children under 8 years of age (due to potential for permanent tooth discoloration and bone growth inhibition)
- Severe hepatic impairment
Drug Interactions
Penicillins
May interfere with the bactericidal action of penicillins.
Oral contraceptives
May reduce efficacy of oral contraceptives. Advise alternative contraception.
Anticoagulants (e.g., Warfarin)
May potentiate anticoagulant effect. Monitor INR.
Antacids, iron supplements, calcium supplements
Decrease doxycycline absorption. Separate administration by at least 2-3 hours.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, and diarrhea. Management is symptomatic and supportive, including gastric lavage or activated charcoal if recent ingestion.
Pregnancy & Lactation
Pregnancy Category D. Doxycycline crosses the placenta and can cause permanent tooth discoloration and bone growth inhibition in the fetus. Avoid during pregnancy and lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Doxycycline has been extensively studied in numerous clinical trials for its efficacy and safety across various bacterial infections and other conditions. Its use is well-established.
Lab Monitoring
- Liver function tests (for prolonged therapy)
- Kidney function tests (if underlying renal disease)
Doctor Notes
- Emphasize the importance of taking with plenty of water and sitting upright for 30-60 minutes.
- Advise patients on sun protection due to photosensitivity.
- Counsel on potential interactions with dairy, antacids, and iron supplements.
Patient Guidelines
- Take with plenty of water to prevent esophageal irritation.
- Avoid direct sunlight and use sunscreen due to photosensitivity.
- Do not take with dairy products, antacids, or iron supplements. Separate by 2-3 hours.
- Complete the full course of medication even if symptoms improve.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances in some individuals. Caution should be exercised when driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Use sun protection (hats, long sleeves) when outdoors.
- Avoid alcohol as it may worsen stomach irritation.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.