Volant
Generic Name
Pregabalin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| volant 75 mg capsule | ৳ 16.00 | ৳ 160.00 |
Description
Overview of the medicine
Volant 75 mg capsule contains Pregabalin, an antiepileptic and anxiolytic drug used to treat neuropathic pain, fibromyalgia, and generalized anxiety disorder.
Uses & Indications
Dosage
Adults
Initial 75 mg twice daily, may be increased to 150-300 mg twice daily, maximum 600 mg/day.
Elderly
Dosage adjustment may be necessary due to reduced renal function.
Renal_impairment
Dosage must be reduced significantly based on creatinine clearance.
How to Take
Administer orally with or without food. Swallow whole with water.
Mechanism of Action
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of several neurotransmitters including glutamate, norepinephrine, and substance P. This results in analgesic, anxiolytic, and anticonvulsant effects.
Pharmacokinetics
Onset
Within 1-2 weeks for pain/anxiety relief, faster for specific indications.
Excretion
Primarily excreted unchanged by the kidneys.
Half life
Approximately 6.3 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached within 1 hour.
Metabolism
Negligible hepatic metabolism, <2% metabolized.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any excipients.
- Angioedema history with ACE inhibitors.
Drug Interactions
Alcohol
Increased risk of CNS depression.
Opioids (e.g., Oxycodone)
Increased risk of respiratory depression and sedation.
Benzodiazepines (e.g., Lorazepam)
Additive CNS depressant effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, agitation, and rarely coma. Treatment is supportive and symptomatic, hemodialysis may be considered in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to fetus. Excreted in breast milk, use with caution.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any excipients.
- Angioedema history with ACE inhibitors.
Drug Interactions
Alcohol
Increased risk of CNS depression.
Opioids (e.g., Oxycodone)
Increased risk of respiratory depression and sedation.
Benzodiazepines (e.g., Lorazepam)
Additive CNS depressant effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, agitation, and rarely coma. Treatment is supportive and symptomatic, hemodialysis may be considered in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to fetus. Excreted in breast milk, use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months
Availability
Pharmacies, Hospitals
Approval Status
DGDA Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials support its efficacy in neuropathic pain, fibromyalgia, and GAD. Ongoing research explores new indications.
Lab Monitoring
- Renal function (creatinine clearance)
- Complete Blood Count (CBC) (rarely for thrombocytopenia)
Doctor Notes
- Counsel patients on the risk of dizziness and somnolence, especially at treatment initiation.
- Monitor for signs of misuse or abuse in susceptible patients.
- Renal dose adjustment is crucial to prevent accumulation and toxicity.
Patient Guidelines
- Do not stop taking this medicine abruptly without consulting your doctor, as it may cause withdrawal symptoms.
- Avoid alcohol consumption while on this medication.
- Report any unusual mood changes or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness, somnolence, and blurred vision. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a balanced diet and regular exercise regimen.
- Avoid activities requiring mental alertness until you know how this medicine affects you.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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