Voltalin-SR
Generic Name
Diclofenac Sodium (Sustained Release)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| voltalin sr 100 mg tablet | ৳ 18.00 | ৳ 180.00 |
Description
Overview of the medicine
Voltalin-SR 100 mg tablet contains Diclofenac Sodium, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and stiffness caused by arthritis and other conditions. The 'SR' indicates sustained release, providing prolonged action.
Uses & Indications
Dosage
Adults
Usually 100 mg once daily. Should be taken with food or milk to minimize gastrointestinal upset. Swallow whole; do not crush, chew, or divide.
Elderly
Use the lowest effective dose for the shortest duration. Monitor for adverse effects, especially gastrointestinal and renal.
Renal_impairment
Use with caution in patients with mild to moderate renal impairment. Avoid in severe renal impairment. Dose adjustment may be necessary based on renal function.
How to Take
Take the tablet whole with a glass of water, preferably during or after a meal, to reduce the risk of gastrointestinal irritation. Do not crush, chew, or break the tablet.
Mechanism of Action
Diclofenac inhibits cyclooxygenase (COX-1 and COX-2) enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins are inflammatory mediators, so by reducing their production, diclofenac decreases inflammation, pain, and fever.
Pharmacokinetics
Onset
Analgesic effects typically begin within 2-3 hours.
Excretion
Approximately 60% is excreted in the urine as metabolites, and about 35% is excreted in bile and feces.
Half life
The elimination half-life is approximately 1-2 hours, but the sustained-release formulation extends its therapeutic action.
Absorption
Well absorbed orally. Peak plasma concentrations are achieved 4-5 hours after administration of the sustained-release tablet, which is delayed compared to immediate-release formulations.
Metabolism
Extensively metabolized in the liver, primarily by hydroxylation and subsequent glucuronidation, mainly by CYP2C9.
Side Effects
Contraindications
- Hypersensitivity to diclofenac or any other NSAID
- Active peptic ulcer or gastrointestinal bleeding
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
- Severe heart failure, renal failure, or hepatic failure
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased lithium plasma levels.
Diuretics
Reduced diuretic effect and increased risk of renal toxicity.
Methotrexate
Increased methotrexate toxicity.
Other NSAIDs or corticosteroids
Increased risk of gastrointestinal adverse effects.
Warfarin and other anticoagulants
Increased risk of bleeding.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
ACE Inhibitors / Angiotensin Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, gastrointestinal bleeding, acute renal failure, and respiratory depression. Management involves symptomatic and supportive treatment. Gastric lavage, activated charcoal, and forced diuresis may be considered.
Pregnancy & Lactation
Pregnancy: Avoid in the third trimester due to potential adverse effects on fetal cardiovascular system (premature closure of ductus arteriosus). Use during first and second trimesters only if clearly needed and under strict medical supervision. Lactation: Diclofenac is excreted in breast milk. Use with caution; consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to diclofenac or any other NSAID
- Active peptic ulcer or gastrointestinal bleeding
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
- Severe heart failure, renal failure, or hepatic failure
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased lithium plasma levels.
Diuretics
Reduced diuretic effect and increased risk of renal toxicity.
Methotrexate
Increased methotrexate toxicity.
Other NSAIDs or corticosteroids
Increased risk of gastrointestinal adverse effects.
Warfarin and other anticoagulants
Increased risk of bleeding.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
ACE Inhibitors / Angiotensin Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, gastrointestinal bleeding, acute renal failure, and respiratory depression. Management involves symptomatic and supportive treatment. Gastric lavage, activated charcoal, and forced diuresis may be considered.
Pregnancy & Lactation
Pregnancy: Avoid in the third trimester due to potential adverse effects on fetal cardiovascular system (premature closure of ductus arteriosus). Use during first and second trimesters only if clearly needed and under strict medical supervision. Lactation: Diclofenac is excreted in breast milk. Use with caution; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Diclofenac has undergone extensive clinical trials supporting its efficacy and safety for various inflammatory and painful conditions. Ongoing research continues to explore its applications and optimize its use.
Lab Monitoring
- Complete Blood Count (CBC) (for long-term therapy)
- Liver Function Tests (LFTs)
- Renal Function Tests (RFTs) (BUN, Creatinine)
- Blood Pressure monitoring
Doctor Notes
- Prescribe the lowest effective dose for the shortest possible duration consistent with treatment goals.
- Carefully assess cardiovascular and gastrointestinal risk factors before initiating and during therapy.
- Monitor blood pressure, renal function, and liver enzymes periodically, especially in elderly or long-term users.
- Advise patients on signs and symptoms of GI bleeding and cardiovascular events.
Patient Guidelines
- Do not exceed the prescribed dose or duration of treatment.
- Report any signs of gastrointestinal bleeding (e.g., black, tarry stools, severe stomach pain) immediately.
- Avoid concomitant use of other NSAIDs or aspirin.
- Consult your doctor if you experience swelling, sudden weight gain, or shortness of breath.
- Take with food or milk to minimize stomach upset.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness, drowsiness, or visual disturbances in some patients. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid excessive alcohol consumption, as it can increase the risk of stomach problems.
- Maintain a balanced diet and stay hydrated.
- Engage in regular, moderate exercise as advised by your physician, if applicable.
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