Vomiset
Generic Name
Ondansetron
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vomiset 8 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Ondansetron is used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery.
Uses & Indications
Dosage
Adults
For chemotherapy-induced nausea and vomiting: Typically 8 mg orally 30 minutes before chemotherapy, followed by 8 mg 8-12 hours later. For PONV: 8 mg orally one hour before anesthesia or 8 mg orally after surgery.
Elderly
No specific dose adjustment is generally required for elderly patients based on age alone, but liver function should be monitored.
Renal_impairment
No dose adjustment is necessary for patients with renal impairment.
How to Take
Take Vomiset-8 mg tablet orally, with or without food, as directed by your doctor. Swallow the tablet whole with water.
Mechanism of Action
Ondansetron selectively blocks serotonin 5-HT3 receptors located both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone, thereby preventing nausea and vomiting.
Pharmacokinetics
Onset
Approximately 30 minutes following oral administration.
Excretion
Approximately 5-10% excreted unchanged in urine. The remainder is excreted as metabolites in urine and feces.
Half life
Approximately 3 to 5 hours in adults, longer in elderly patients and those with severe hepatic impairment.
Absorption
Rapid and complete absorption from the gastrointestinal tract, with bioavailability of approximately 60% due to first-pass metabolism.
Metabolism
Extensive hepatic metabolism, primarily via hydroxylation followed by glucuronide or sulfate conjugation. Involves CYP1A2, CYP2D6, and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to ondansetron or any component of the formulation.
- Concomitant use with apomorphine due to the risk of profound hypotension and loss of consciousness.
Drug Interactions
Tramadol
Ondansetron may reduce the analgesic effect of tramadol.
Apomorphine
Concomitant use is contraindicated due to severe hypotension and loss of consciousness.
Phenytoin, Carbamazepine, Rifampicin
May decrease ondansetron plasma concentrations due to enzyme induction.
QT-prolonging drugs (e.g., Amiodarone, Chlorpromazine)
Increased risk of QT interval prolongation and torsades de pointes. Concurrent use should be approached with caution.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include transient visual disturbances, severe constipation, hypotension, and a vasovagal episode with transient AV block. Treatment should be symptomatic and supportive, as there is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown a risk, but well-controlled human studies are lacking. Use only if clearly needed. Ondansetron is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to ondansetron or any component of the formulation.
- Concomitant use with apomorphine due to the risk of profound hypotension and loss of consciousness.
Drug Interactions
Tramadol
Ondansetron may reduce the analgesic effect of tramadol.
Apomorphine
Concomitant use is contraindicated due to severe hypotension and loss of consciousness.
Phenytoin, Carbamazepine, Rifampicin
May decrease ondansetron plasma concentrations due to enzyme induction.
QT-prolonging drugs (e.g., Amiodarone, Chlorpromazine)
Increased risk of QT interval prolongation and torsades de pointes. Concurrent use should be approached with caution.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include transient visual disturbances, severe constipation, hypotension, and a vasovagal episode with transient AV block. Treatment should be symptomatic and supportive, as there is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown a risk, but well-controlled human studies are lacking. Use only if clearly needed. Ondansetron is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture when stored correctly.
Availability
Pharmacies, hospitals
Approval Status
Approved by DGDA
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Ondansetron has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in preventing chemotherapy-induced, radiation-induced, and post-operative nausea and vomiting across various patient populations.
Lab Monitoring
- ECG monitoring is recommended in patients with underlying cardiac conditions, electrolyte abnormalities (hypokalemia, hypomagnesemia), or those taking other QT-prolonging drugs.
- Liver function tests should be monitored periodically in patients with severe hepatic impairment.
Doctor Notes
- Always assess for risk factors of QT prolongation (e.g., electrolyte imbalances, congenital long QT syndrome, concomitant QT-prolonging drugs) before prescribing, and consider ECG monitoring if indicated.
- Advise patients on common side effects such as headache and constipation, and when to seek medical attention for more serious symptoms like chest pain or irregular heartbeat.
Patient Guidelines
- Always take this medicine exactly as your doctor has told you.
- Do not exceed the recommended dose, as it may increase the risk of side effects, including heart rhythm changes.
- Inform your doctor or pharmacist if you are taking any other medications, including over-the-counter drugs or herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Vomiset-8 mg may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hydration, especially during chemotherapy, to help manage side effects.
- Avoid alcohol if it exacerbates nausea or causes dizziness.
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