Vonolend
Generic Name
Vonoprazan Fumarate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vonolend 20 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Vonolend 20 mg Tablet contains Vonoprazan, a potassium-competitive acid blocker (P-CAB) used to treat acid-related disorders such as gastric ulcers, duodenal ulcers, and reflux esophagitis, and as an adjunct in H. pylori eradication therapy.
Uses & Indications
Dosage
Adults
Gastric ulcer: 20 mg once daily for 8 weeks. Duodenal ulcer: 20 mg once daily for 6 weeks. Reflux esophagitis: 20 mg once daily for 4 weeks (up to 8 weeks if necessary). H. pylori eradication: 20 mg twice daily in combination with two antibiotics for 7 days.
Elderly
No specific dosage adjustment is usually required, but monitor for adverse effects.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Use with caution and monitor closely in severe renal impairment.
How to Take
Take orally, with or without food. For H. pylori eradication, take with food. Usually taken once daily, preferably in the morning before breakfast.
Mechanism of Action
Vonoprazan acts by reversibly inhibiting the H+/K+-ATPase enzyme (proton pump) in the gastric parietal cells, thereby blocking the final step of acid secretion into the stomach lumen. Unlike traditional PPIs, it does not require acid activation and binds to the pump regardless of its activation state.
Pharmacokinetics
Onset
Onset of acid suppression occurs within hours of the first dose.
Excretion
Approximately 50% excreted via urine and 50% via feces.
Half life
Plasma elimination half-life is approximately 7-9 hours.
Absorption
Rapidly absorbed after oral administration, reaching peak plasma concentrations (Cmax) in 1-2 hours. Bioavailability is high.
Metabolism
Primarily metabolized by CYP3A4, with minor contributions from CYP2B6, CYP2C19, and CYP2D6 enzymes.
Side Effects
Contraindications
- Hypersensitivity to vonoprazan or any component of the formulation
- Concomitant use with atazanavir or nelfinavir
Drug Interactions
Clopidogrel
Potential for reduced antiplatelet effect, though less significant than with some PPIs.
Methotrexate
Possible increase in methotrexate exposure; monitor closely.
Atazanavir, Nelfinavir
Reduced antiviral efficacy due to decreased absorption.
Drugs metabolized by CYP3A4
Potential for altered metabolism of co-administered drugs.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote.
Pregnancy & Lactation
Pregnancy: Use only if clearly needed and the potential benefit outweighs the potential risk. Animal studies showed no teratogenicity, but human data are limited. Lactation: It is unknown whether vonoprazan is excreted in human milk. Caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Pharmacies nationwide
Approval Status
DGDA Approved
Patent Status
Patent Protected (in some regions)
Clinical Trials
Vonoprazan has undergone extensive phase II and phase III clinical trials demonstrating its efficacy and safety in various acid-related disorders and H. pylori eradication.
Lab Monitoring
- Liver function tests (baseline and periodically for long-term use)
- Renal function tests (for patients with severe renal impairment)
- Serum gastrin levels (for very long-term use, if clinically indicated)
Doctor Notes
- Vonoprazan offers a distinct advantage over PPIs due to its acid stability and potassium-competitive binding, leading to faster and more potent acid suppression.
- Consider for patients who are unresponsive to conventional PPI therapy.
- Always inquire about concomitant medications, especially antivirals like atazanavir or nelfinavir, which are contraindicated.
Patient Guidelines
- Take Vonolend exactly as prescribed by your doctor.
- Do not crush, chew, or break the tablet; swallow it whole.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Do not stop taking the medicine abruptly without consulting your doctor, even if you feel better.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Vonolend is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Avoid trigger foods and beverages that worsen acid reflux (e.g., spicy foods, caffeine, alcohol).
- Maintain a healthy diet and lifestyle.
- For reflux symptoms, elevate the head of your bed during sleep.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.