Vonopa
Generic Name
Vonoprazan 10 mg Tablet
Manufacturer
Leading Pharmaceutical Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vonopa 10 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Vonoprazan is a potassium-competitive acid blocker (P-CAB) used for the treatment of acid-related disorders. It effectively suppresses gastric acid secretion, providing rapid and sustained relief from symptoms and aiding in ulcer healing.
Uses & Indications
Dosage
Adults
For gastric ulcer: 20 mg once daily for 8 weeks. For duodenal ulcer: 20 mg once daily for 6 weeks. For reflux esophagitis: 20 mg once daily for 4-8 weeks. For H. pylori eradication: 20 mg twice daily for 7 days in combination with antibiotics.
Elderly
No specific dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment required for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Take the tablet orally, with or without food. Swallow the tablet whole with water; do not crush, chew, or break it.
Mechanism of Action
Vonoprazan reversibly and competitively inhibits H+/K+-ATPase (the proton pump) in the gastric parietal cells, thereby blocking the final step of acid secretion. Its binding is potassium-competitive, leading to potent and prolonged acid suppression independent of proton pump activation.
Pharmacokinetics
Onset
Acid suppression begins within 1-2 hours.
Excretion
Excreted renally (approx. 50%) and fecally (approx. 35%).
Half life
Approximately 7-9 hours, longer than most PPIs.
Absorption
Rapidly absorbed after oral administration, reaching peak plasma concentrations within 1.5-2 hours.
Metabolism
Primarily metabolized by cytochrome P450 enzymes, mainly CYP3A4, and to a lesser extent by CYP2B6, CYP2C19, and CYP2D6.
Side Effects
Contraindications
- Hypersensitivity to vonoprazan or any component of the formulation.
- Coadministration with atazanavir or nelfinavir due to potential significant reduction in their plasma concentrations.
Drug Interactions
Clopidogrel
Vonoprazan may reduce the antiplatelet effect of clopidogrel, though clinical significance is still under investigation.
Atazanavir/Nelfinavir
Coadministration is contraindicated due to decreased plasma levels of these antivirals.
pH-dependent absorption drugs (e.g., Ketoconazole, Itraconazole)
Absorption may be altered due to changes in intragastric pH.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, provide symptomatic and supportive treatment. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed and potential benefits outweigh risks. Advise against use during lactation as it is unknown if vonoprazan is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to vonoprazan or any component of the formulation.
- Coadministration with atazanavir or nelfinavir due to potential significant reduction in their plasma concentrations.
Drug Interactions
Clopidogrel
Vonoprazan may reduce the antiplatelet effect of clopidogrel, though clinical significance is still under investigation.
Atazanavir/Nelfinavir
Coadministration is contraindicated due to decreased plasma levels of these antivirals.
pH-dependent absorption drugs (e.g., Ketoconazole, Itraconazole)
Absorption may be altered due to changes in intragastric pH.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, provide symptomatic and supportive treatment. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed and potential benefits outweigh risks. Advise against use during lactation as it is unknown if vonoprazan is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from manufacturing date.
Availability
Available in pharmacies
Approval Status
Approved in various countries (e.g., Japan, USA, Bangladesh)
Patent Status
Patented, generics available in some regions
Clinical Trials
Extensive clinical trials have demonstrated its efficacy and safety in various acid-related disorders. Ongoing studies explore its potential in other gastrointestinal conditions.
Lab Monitoring
- Liver function tests (especially with long-term use or in patients with hepatic impairment).
Doctor Notes
- Consider for patients with refractory GERD or H. pylori infection unresponsive to standard PPI regimens.
- Monitor liver function tests, especially in patients with pre-existing hepatic impairment.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Report any severe or persistent side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Vonoprazan may cause dizziness in some individuals. If you experience dizziness, avoid driving or operating heavy machinery.
Lifestyle Advice
- Avoid trigger foods such as spicy, fatty, or acidic foods if they worsen your acid reflux symptoms.
- Avoid alcohol and smoking as they can exacerbate acid-related conditions.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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