Vorifast
Generic Name
Voriconazole
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vorifast 200 mg tablet | ৳ 110.00 | ৳ 1,100.00 |
Description
Overview of the medicine
Vorifast 200 mg Tablet is an antifungal medication used to treat serious fungal infections caused by susceptible strains of fungi.
Uses & Indications
Dosage
Adults
Loading dose: 400 mg every 12 hours for 2 doses. Maintenance dose: 200 mg every 12 hours, adjusted based on patient response and tolerability.
Elderly
No dose adjustment is generally required, but caution is advised due to potential age-related organ function decline.
Renal_impairment
No dose adjustment is required for patients with mild to severe renal impairment (CrCl ≥ 30 mL/min). Monitor carefully. For severe impairment, consider alternative therapies.
How to Take
Take on an empty stomach, at least one hour before or one hour after a meal. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Voriconazole inhibits fungal cytochrome P450-mediated 14 alpha-lanosterol demethylation, an essential step in fungal ergosterol biosynthesis. This leads to the accumulation of 14 alpha-methyl sterols and a decrease in ergosterol, causing disruption of fungal membrane function and growth.
Pharmacokinetics
Onset
Typically within 1-2 hours for therapeutic levels.
Excretion
Primarily via hepatic metabolism, with less than 2% excreted unchanged in urine.
Half life
Variable, dose-dependent, but generally 6 hours to 10 hours at therapeutic doses.
Absorption
Well absorbed orally, bioavailability approximately 90%.
Metabolism
Extensively metabolized by hepatic cytochrome P450 enzymes (CYP2C19, CYP2F9, CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to voriconazole or any component of the formulation
- Co-administration with terfenadine, astemizole, cisapride, pimozide, quinidine, rifampin, carbamazepine, phenobarbital, sirolimus, or ergot alkaloids
Drug Interactions
Rifampin
Significant decrease in voriconazole plasma concentrations.
Phenytoin
Significant decrease in voriconazole plasma concentrations, monitor phenytoin levels.
Cyclosporine
Increased cyclosporine levels, monitor cyclosporine levels and adjust dose.
Carbamazepine
Significant decrease in voriconazole plasma concentrations.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, discontinue voriconazole and provide supportive care. Voriconazole is hemodialyzable.
Pregnancy & Lactation
Pregnancy Category D. Should not be used during pregnancy unless the benefits outweigh the potential risks. Not recommended during breastfeeding as it may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to voriconazole or any component of the formulation
- Co-administration with terfenadine, astemizole, cisapride, pimozide, quinidine, rifampin, carbamazepine, phenobarbital, sirolimus, or ergot alkaloids
Drug Interactions
Rifampin
Significant decrease in voriconazole plasma concentrations.
Phenytoin
Significant decrease in voriconazole plasma concentrations, monitor phenytoin levels.
Cyclosporine
Increased cyclosporine levels, monitor cyclosporine levels and adjust dose.
Carbamazepine
Significant decrease in voriconazole plasma concentrations.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, discontinue voriconazole and provide supportive care. Voriconazole is hemodialyzable.
Pregnancy & Lactation
Pregnancy Category D. Should not be used during pregnancy unless the benefits outweigh the potential risks. Not recommended during breastfeeding as it may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available, patent expired for original compound
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of voriconazole in treating various fungal infections, leading to its approval. Ongoing post-marketing surveillance and studies continue to refine understanding.
Lab Monitoring
- Liver function tests (ALT, AST, alkaline phosphatase, bilirubin)
- Renal function tests (creatinine, BUN)
- Electrolytes (potassium, magnesium)
- Visual function (ophthalmological examination for long-term therapy)
Doctor Notes
- Consider therapeutic drug monitoring (TDM) for voriconazole, especially in patients with altered hepatic function, drug interactions, or inadequate clinical response/toxicity.
- Be aware of the non-linear pharmacokinetics and the potential for significant drug interactions.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not stop taking this medicine suddenly without consulting your doctor.
- Report any new or worsening side effects, especially visual disturbances, skin reactions, or signs of liver problems.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Voriconazole can cause visual disturbances, including blurred vision, altered light perception, and photophobia. Patients should be warned not to drive or operate machinery if they experience these effects.
Lifestyle Advice
- Avoid direct sunlight or use sunscreen and protective clothing due to increased photosensitivity.
- Maintain good hydration.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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