Winolip
Generic Name
Fenofibrate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| winolip 180 mg tablet | ৳ 30.00 | ৳ 300.00 |
Description
Overview of the medicine
Winolip 180 mg Tablet is a lipid-lowering medication used to reduce high cholesterol and triglyceride levels in the blood. It belongs to a group of medicines called fibrates. It works by reducing the production of 'bad' cholesterol (LDL) and triglycerides and increasing the production of 'good' cholesterol (HDL).
Uses & Indications
Dosage
Adults
180 mg once daily with food. Dosage should be individualized based on patient response and lipid levels.
Elderly
Similar to adult dosage, but caution should be exercised and renal function monitored.
Renal_impairment
Contraindicated in severe renal impairment (eGFR < 30 mL/min/1.73m²). For moderate impairment (eGFR 30-59 mL/min/1.73m²), consider a lower dose or avoid if possible.
How to Take
Take orally, once daily with a meal to enhance absorption. Swallow the tablet whole; do not crush or chew.
Mechanism of Action
Fenofibrate, a fibric acid derivative, acts by activating peroxisome proliferator-activated receptor alpha (PPAR-alpha). This activation leads to increased lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing the production of apoprotein C-III. It also increases the synthesis of apoproteins A-I and A-II, leading to an increase in HDL-cholesterol.
Pharmacokinetics
Onset
Lipid-lowering effects typically observed within 2-5 days, maximal effects by 4-8 weeks.
Excretion
Mainly excreted in the urine as fenofibric acid and its glucuronide conjugate. A small amount is excreted in the feces.
Half life
Approximately 20-23 hours for the active metabolite (fenofibric acid).
Absorption
Well absorbed after oral administration, especially with food. Peak plasma levels reached within 4-5 hours.
Metabolism
Fenofibrate is rapidly hydrolyzed by esterases to its active metabolite, fenofibric acid, which is then conjugated with glucuronic acid.
Side Effects
Contraindications
- Severe renal impairment (eGFR < 30 mL/min/1.73m²)
- Active liver disease, including primary biliary cirrhosis and unexplained persistent liver function abnormalities
- Pre-existing gallbladder disease
- Hypersensitivity to fenofibrate or any component of the formulation
- Known photoallergy or phototoxic reaction during treatment with fibrates or ketoprofen
Drug Interactions
Warfarin
Potentiates the anticoagulant effect of warfarin, increasing the risk of bleeding. Monitor INR closely.
Cyclosporine
Increased risk of renal dysfunction. Monitor renal function.
Statins (HMG-CoA Reductase Inhibitors)
Increased risk of myopathy/rhabdomyolysis. Use with caution, especially at higher doses of statins.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Treatment of overdose should be symptomatic and supportive. Gastric lavage or activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding due to lack of data on excretion in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Generic available
Clinical Trials
Fenofibrate has been extensively studied in numerous clinical trials, demonstrating efficacy in reducing triglycerides and LDL-C, and increasing HDL-C. Key trials include FIELD (Fenofibrate Intervention and Event Lowering in Diabetes) and ACCORD Lipid (Action to Control Cardiovascular Risk in Diabetes) which evaluated its cardiovascular outcomes.
Lab Monitoring
- Liver function tests (ALT, AST) periodically, especially during the first year of treatment.
- Renal function (creatinine, eGFR) periodically.
- Lipid panel (total cholesterol, LDL-C, HDL-C, triglycerides) to assess efficacy.
Doctor Notes
- Emphasize adherence to diet and exercise.
- Monitor LFTs and renal function prior to and during therapy.
- Counsel patients on symptoms of myopathy and gallstones.
Patient Guidelines
- Take with food as directed.
- Do not stop taking this medication without consulting your doctor.
- Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately.
- Regular monitoring of blood tests will be necessary.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Fenofibrate is not expected to affect the ability to drive or operate machinery. However, if you experience dizziness, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a low-fat, low-cholesterol diet.
- Engage in regular physical activity.
- Avoid excessive alcohol consumption.
- Quit smoking.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.