Xadu
Generic Name
Serotonin Modulator 50 mg
Manufacturer
Global Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xadu 50 mg tablet | ৳ 350.00 | ৳ 2,100.00 |
Description
Overview of the medicine
Xadu 50 mg Tablet is an antidepressant primarily used to treat major depressive disorder, generalized anxiety disorder, and panic disorder. It works by affecting the balance of neurotransmitters in the brain.
Uses & Indications
Dosage
Adults
Initial dose 50 mg once daily, preferably in the morning. May be increased gradually to a maximum of 200 mg daily based on clinical response.
Elderly
Starting dose 25 mg once daily, may be increased cautiously. Max 100 mg daily.
Renal_impairment
No dosage adjustment needed for mild to moderate impairment. Use with caution in severe impairment.
How to Take
Take orally, with or without food. It is recommended to take it at the same time each day.
Mechanism of Action
Xadu acts as a selective serotonin reuptake inhibitor (SSRI), increasing the extracellular level of the neurotransmitter serotonin by limiting its reabsorption into the presynaptic cell. This enhances serotonergic neurotransmission.
Pharmacokinetics
Onset
Initial effects typically within 1-2 weeks; full therapeutic effect may take 4-6 weeks.
Excretion
Excreted primarily via urine (60%) and feces (40%) as metabolites.
Half life
Approximately 20-25 hours.
Absorption
Well absorbed orally; peak plasma concentrations reached within 4-8 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Xadu or any components of the formulation.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI treatment.
- Concomitant use with Pimozide.
Drug Interactions
MAOIs
Risk of serious, sometimes fatal, serotonin syndrome. Avoid concomitant use.
Warfarin
May increase bleeding risk; monitor INR.
CYP2D6 inhibitors
May increase Xadu levels.
Other serotonergic drugs (e.g., Triptans, Tramadol)
Increased risk of serotonin syndrome.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, nausea, vomiting, tachycardia, tremor, and dizziness. In severe cases, seizures, coma, and serotonin syndrome can occur. Treatment is supportive and symptomatic; maintain airway, monitor cardiac and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Patent pending
Clinical Trials
Extensive clinical trials have demonstrated Xadu's efficacy and safety in the treatment of various depressive and anxiety disorders. Studies show significant improvement in HAM-D and HAM-A scores compared to placebo.
Lab Monitoring
- Monitor for hyponatremia, especially in elderly patients or those taking diuretics.
- Liver and renal function tests if clinically indicated.
Doctor Notes
- Advise patients about the delayed onset of action and the importance of continued treatment.
- Monitor for signs of serotonin syndrome, especially when co-administered with other serotonergic agents.
- Regularly assess for suicidal ideation, particularly at the beginning of treatment or after dose changes.
Patient Guidelines
- Do not stop taking Xadu abruptly without consulting your doctor, as withdrawal symptoms may occur.
- It may take several weeks to feel the full benefits of this medicine.
- Report any worsening of depression or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose.
Driving Precautions
Xadu may cause dizziness, drowsiness, or blurred vision. Patients should be advised to exercise caution when driving or operating machinery until they are reasonably certain that Xadu does not adversely affect their ability.
Lifestyle Advice
- Avoid alcohol consumption while on Xadu.
- Maintain a regular sleep schedule.
- Engage in physical activity to support mental well-being.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.