Xanbac
Generic Name
xanbac-10-mg-tablet
Manufacturer
MediPharm Bangladesh Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xanbac 10 mg tablet | ৳ 8.00 | N/A |
Description
Overview of the medicine
Xanbac 10 mg tablet contains Xanbacine, a GABA-A receptor modulator, primarily used for the short-term management of anxiety disorders, insomnia, and as a pre-operative sedative. It helps to calm the brain and nerves.
Uses & Indications
Dosage
Adults
Generalized anxiety disorder: Initially 5 mg, 2-3 times daily, adjusted to a usual dose of 10-20 mg daily in divided doses. Panic disorder: Initially 5 mg once daily at bedtime, adjusted up to 30 mg daily.
Elderly
Initial dose should be half of the adult dose (e.g., 2.5 mg 2-3 times daily), adjusted carefully due to increased sensitivity and risk of adverse effects.
Renal_impairment
Use with caution. Dosage reduction may be necessary in severe impairment. Start with lower doses.
How to Take
Take orally with or without food. Do not crush or chew the tablet. Swallow whole with water.
Mechanism of Action
Xanbacine selectively binds to GABA-A receptors in the central nervous system, enhancing the inhibitory effects of gamma-aminobutyric acid (GABA). This leads to increased chloride ion influx into neurons, resulting in hyperpolarization and reduced neuronal excitability, thus producing anxiolytic, sedative, hypnotic, and muscle relaxant effects.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Primarily excreted in the urine as metabolites.
Half life
Approximately 10-14 hours (active metabolites may extend duration)
Absorption
Rapidly and completely absorbed after oral administration, peak plasma concentrations reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver via CYP3A4 enzymes, forming active and inactive metabolites.
Side Effects
Contraindications
- Known hypersensitivity to Xanbacine or other benzodiazepines
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
- Severe hepatic impairment
- Myasthenia gravis
Drug Interactions
Opioids
Increased risk of respiratory depression, profound sedation, coma, and death.
Antifungals (e.g., Ketoconazole)
May inhibit metabolism of Xanbacine, leading to increased plasma levels and enhanced effects.
Alcohol and other CNS depressants
Potentiation of sedative effects, increased risk of respiratory depression.
CYP3A4 inducers (e.g., Rifampicin)
Can decrease Xanbacine levels and efficacy.
CYP3A4 inhibitors (e.g., Grapefruit juice)
Can increase Xanbacine levels and effects.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, impaired coordination, diminished reflexes, and coma. Management involves supportive care, maintaining airway, and monitoring vital signs. Flumazenil may be used as an antidote, but with caution due to risk of withdrawal seizures.
Pregnancy & Lactation
Pregnancy Category D. Xanbacine can cause fetal harm. Avoid during pregnancy. Excreted in breast milk, avoid during breastfeeding or monitor infant for sedation/feeding difficulties.
Side Effects
Contraindications
- Known hypersensitivity to Xanbacine or other benzodiazepines
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
- Severe hepatic impairment
- Myasthenia gravis
Drug Interactions
Opioids
Increased risk of respiratory depression, profound sedation, coma, and death.
Antifungals (e.g., Ketoconazole)
May inhibit metabolism of Xanbacine, leading to increased plasma levels and enhanced effects.
Alcohol and other CNS depressants
Potentiation of sedative effects, increased risk of respiratory depression.
CYP3A4 inducers (e.g., Rifampicin)
Can decrease Xanbacine levels and efficacy.
CYP3A4 inhibitors (e.g., Grapefruit juice)
Can increase Xanbacine levels and effects.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, impaired coordination, diminished reflexes, and coma. Management involves supportive care, maintaining airway, and monitoring vital signs. Flumazenil may be used as an antidote, but with caution due to risk of withdrawal seizures.
Pregnancy & Lactation
Pregnancy Category D. Xanbacine can cause fetal harm. Avoid during pregnancy. Excreted in breast milk, avoid during breastfeeding or monitor infant for sedation/feeding difficulties.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
Clinical Trials
Clinical trials demonstrated efficacy in reducing anxiety symptoms compared to placebo. Further studies are ongoing to evaluate long-term safety and dependence potential.
Lab Monitoring
- Liver function tests (baseline and periodically, especially in long-term use)
- Renal function tests (in patients with impairment)
Doctor Notes
- Emphasize short-term use and gradual tapering. Assess for co-morbid substance use disorders.
- Educate patients on potential for dependence and withdrawal symptoms. Regularly reassess the need for continued treatment.
Patient Guidelines
- Do not stop taking Xanbac suddenly, as it may cause withdrawal symptoms. Consult your doctor for gradual dose reduction.
- Avoid alcohol and other CNS depressants during treatment.
- Do not drive or operate heavy machinery until you know how Xanbac affects you.
- Report any unusual mood changes or severe side effects to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Xanbac can cause drowsiness, dizziness, and impaired coordination. Do not drive or operate dangerous machinery until you know how this medicine affects you and are certain you can perform these tasks safely.
Lifestyle Advice
- Practice good sleep hygiene (consistent sleep schedule, comfortable environment).
- Engage in stress-reducing activities like meditation or yoga.
- Maintain a balanced diet and regular exercise.
- Limit caffeine intake, especially in the evening.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.