Xaparin
Generic Name
Enoxaparin Sodium
Manufacturer
Opso Saline Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xaparin 4000 anti xa injection | ৳ 440.00 | N/A |
Description
Overview of the medicine
Xaparin 4000 anti-Xa injection contains Enoxaparin Sodium, a low molecular weight heparin, used to prevent and treat blood clots in various medical conditions.
Uses & Indications
Dosage
Adults
DVT prophylaxis: 20-40 mg (2000-4000 anti-Xa IU) subcutaneously once daily. DVT/PE treatment: 1 mg/kg (100 anti-Xa IU/kg) subcutaneously every 12 hours.
Elderly
No dose adjustment generally required unless severe renal impairment. Careful monitoring is advised.
Renal_impairment
Dosage adjustment required for severe renal impairment (CrCl < 30 mL/min). For prophylaxis, 20 mg once daily.
How to Take
Administer by subcutaneous injection, typically into the anterolateral or posterolateral abdominal wall, or outer aspect of the thigh. Do not inject intramuscularly. Alternate injection sites.
Mechanism of Action
Binds to antithrombin, accelerating its inhibition of Factor Xa and to a lesser extent Factor IIa (thrombin), preventing clot formation.
Pharmacokinetics
Onset
Rapid onset of action, within hours.
Excretion
Mainly renal, as active and inactive fragments.
Half life
Approximately 4-5 hours (anti-Xa activity) after a single subcutaneous dose; can be longer in renal impairment.
Absorption
High bioavailability after subcutaneous injection (approx. 100%). Peak anti-Xa activity 3-5 hours post-dose.
Metabolism
Primarily hepatic desulfation and depolymerization into lower molecular weight fragments.
Side Effects
Contraindications
- Hypersensitivity to enoxaparin, heparin, or porcine products
- Active major bleeding
- History of heparin-induced thrombocytopenia (HIT) with or without thrombosis
- Acute bacterial endocarditis
- Spinal or epidural anesthesia in patients on therapeutic enoxaparin
Drug Interactions
Dextran
Increased risk of bleeding.
Warfarin
Increased risk of bleeding; monitor INR closely.
NSAIDs (e.g., ibuprofen)
Increased risk of bleeding.
Antiplatelet agents (e.g., aspirin, clopidogrel)
Increased risk of bleeding.
Storage
Store at room temperature (20-25°C or 68-77°F). Do not freeze. Protect from light. Keep out of reach of children.
Overdose
Accidental overdose may lead to hemorrhagic complications. Manage by discontinuing enoxaparin and administering protamine sulfate for severe bleeding. Monitor coagulation parameters.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and potential benefits outweigh risks, under strict medical supervision. Generally considered safe during lactation, but caution advised.
Side Effects
Contraindications
- Hypersensitivity to enoxaparin, heparin, or porcine products
- Active major bleeding
- History of heparin-induced thrombocytopenia (HIT) with or without thrombosis
- Acute bacterial endocarditis
- Spinal or epidural anesthesia in patients on therapeutic enoxaparin
Drug Interactions
Dextran
Increased risk of bleeding.
Warfarin
Increased risk of bleeding; monitor INR closely.
NSAIDs (e.g., ibuprofen)
Increased risk of bleeding.
Antiplatelet agents (e.g., aspirin, clopidogrel)
Increased risk of bleeding.
Storage
Store at room temperature (20-25°C or 68-77°F). Do not freeze. Protect from light. Keep out of reach of children.
Overdose
Accidental overdose may lead to hemorrhagic complications. Manage by discontinuing enoxaparin and administering protamine sulfate for severe bleeding. Monitor coagulation parameters.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and potential benefits outweigh risks, under strict medical supervision. Generally considered safe during lactation, but caution advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, refer to the product label for exact expiry date.
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Enoxaparin has undergone extensive clinical trials demonstrating its efficacy and safety for preventing and treating various thromboembolic conditions across different patient populations.
Lab Monitoring
- Complete Blood Count (CBC) with platelet count (before treatment and regularly thereafter)
- Anti-Xa levels (in certain populations like obese, renal impairment, pregnancy, or if bleeding suspected)
- Renal function tests (e.g., creatinine clearance)
Doctor Notes
- Emphasize the importance of patient education regarding proper subcutaneous injection technique and safe disposal of needles.
- Monitor patients for signs of bleeding, particularly those on concomitant antiplatelet or anticoagulant therapy.
- Assess renal function prior to initiation and periodically during treatment, especially in elderly or renally impaired patients, to guide dose adjustments.
- Be aware of the black box warning concerning neuraxial anesthesia.
Patient Guidelines
- Report any unusual bleeding, bruising, or adverse reactions immediately to your healthcare provider.
- Do not rub the injection site after administration; dispose of used syringes safely.
- Inform your doctor or dentist about your enoxaparin use before any surgery or dental procedure.
- Do not stop the medication without consulting your doctor, even if you feel better.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose to catch up.
Driving Precautions
Xaparin does not usually affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid driving.
Lifestyle Advice
- Avoid activities that may cause injury or bleeding, especially contact sports.
- Inform family members or caregivers about your anticoagulant therapy.
- Maintain hydration and follow a balanced diet as advised by your doctor.
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