Take the tablet orally, swallow whole with a glass of water, and do not crush, chew, or break it. It can be taken with or without food, but taking it with food may reduce gastrointestinal upset.

As a hypothetical NSAID, Xcel-ER is believed to inhibit cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins mediate pain, inflammation, and fever. By inhibiting their production, Xcel-ER reduces these symptoms.

• •Known hypersensitivity to the active ingredient or any excipients, or to other NSAIDs or aspirin.
• •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
• •Active or recent history of recurrent peptic ulcer/hemorrhage (two or more distinct episodes of proven ulceration or bleeding).
• •Severe heart failure, severe hepatic insufficiency, or severe renal insufficiency (CrCl < 30 mL/min).
• •Third trimester of pregnancy.

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Rare cases of acute renal failure, hypertension, respiratory depression, and coma have occurred. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered if ingestion is recent. Monitor renal function and electrolyte balance.

Pregnancy Category C (first and second trimesters), Category D (third trimester). Use during the third trimester is contraindicated due to potential for premature closure of the fetal ductus arteriosus. Not recommended during breastfeeding as NSAIDs may pass into breast milk and potentially harm the infant.