Xclor
Generic Name
Cefaclor
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xclor 125 mg suspension | ৳ 190.57 | N/A |
Description
Overview of the medicine
Xclor 125 mg Suspension is an antibiotic from the cephalosporin group, used to treat various bacterial infections like respiratory tract infections, ear infections, skin and soft tissue infections, and urinary tract infections.
Uses & Indications
Dosage
Adults
Usually 250 mg every 8 hours, or 500 mg every 8 hours for more severe infections. Max 4 g/day. (Note: 125 mg suspension is typically for pediatric use, but general adult information is provided).
Elderly
No specific dose adjustment for elderly patients with normal renal function, but monitor renal function.
Renal_impairment
Dosage adjustment is necessary for patients with severe renal impairment (creatinine clearance < 10 mL/min). Administer the usual initial dose, then reduce subsequent doses.
How to Take
Shake well before use. May be taken with or without food. Complete the full course of treatment as prescribed, even if symptoms improve.
Mechanism of Action
Cefaclor inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Onset of antibacterial action typically within 30-60 minutes.
Excretion
Primarily excreted unchanged in the urine by glomerular filtration and tubular secretion.
Half life
Elimination half-life is approximately 0.5 to 1 hour in individuals with normal renal function.
Absorption
Well absorbed from the gastrointestinal tract. Peak plasma concentrations are generally achieved within 0.5 to 1 hour after administration.
Metabolism
Cefaclor is minimally metabolized in the body; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefaclor or any other cephalosporin antibiotics
- History of severe hypersensitivity to penicillin antibiotics
Drug Interactions
Metformin
Potential for reduced metformin excretion, though clinically significant interactions are rare.
Probenecid
Increases cefaclor plasma levels and prolongs its half-life by inhibiting renal excretion.
Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect, requiring closer monitoring of INR.
Storage
Store dry powder below 30°C. Keep away from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard unused portion after 14 days.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric distress, and diarrhea. Management includes supportive care and activated charcoal if ingestion is recent. Hemodialysis may be useful in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Cefaclor should be used during pregnancy only if clearly needed. Small amounts are excreted in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to cefaclor or any other cephalosporin antibiotics
- History of severe hypersensitivity to penicillin antibiotics
Drug Interactions
Metformin
Potential for reduced metformin excretion, though clinically significant interactions are rare.
Probenecid
Increases cefaclor plasma levels and prolongs its half-life by inhibiting renal excretion.
Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect, requiring closer monitoring of INR.
Storage
Store dry powder below 30°C. Keep away from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard unused portion after 14 days.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric distress, and diarrhea. Management includes supportive care and activated charcoal if ingestion is recent. Hemodialysis may be useful in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Cefaclor should be used during pregnancy only if clearly needed. Small amounts are excreted in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months for powder, 14 days after reconstitution when stored at recommended conditions.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have established cefaclor's efficacy and safety for bacterial infections across various patient populations since its approval.
Lab Monitoring
- Renal function tests (for prolonged therapy or in impaired renal function)
- Complete blood count (for prolonged therapy)
Doctor Notes
- Confirm bacterial infection before prescribing.
- Advise patients on completing the full course.
- Monitor for hypersensitivity reactions, especially in penicillin-allergic patients.
Patient Guidelines
- Complete the entire course of medication as prescribed.
- Do not save medication for future infections.
- Shake the suspension well before each use.
- Measure the dose accurately using the provided measuring device.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefaclor is generally not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Drink plenty of fluids.
- Avoid alcohol during treatment as it may worsen some side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.