Xelobine
Generic Name
Xelofloxacin 500 mg Tablet
Manufacturer
PharmaGlobal Inc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xelobine 500 mg tablet | ৳ 138.00 | ৳ 1,380.00 |
Description
Overview of the medicine
Xelobine 500 mg Tablet is a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
500 mg orally once daily for 7-14 days, depending on the infection type and severity.
Elderly
No specific dosage adjustment is usually required for elderly patients unless they have significant renal impairment.
Renal_impairment
Dosage reduction is required for patients with creatinine clearance <50 mL/min. For CrCl 20-49 mL/min: 250 mg daily; for CrCl <20 mL/min: 250 mg every 48 hours.
How to Take
Take orally with or without food. Avoid taking antacids, sucralfate, iron supplements, or zinc supplements within 2 hours before or after Xelobine.
Mechanism of Action
Xelofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
1-2 hours
Excretion
Primarily renal excretion (60-70% as unchanged drug); minor fecal excretion.
Half life
6-8 hours
Absorption
Rapidly and well absorbed orally, bioavailability approximately 99%. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Minimally metabolized in the liver, primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Xelofloxacin or other fluoroquinolones
- History of tendon rupture associated with fluoroquinolone use
- Patients with myasthenia gravis
Drug Interactions
NSAIDs
May increase the risk of CNS stimulation and convulsive seizures.
Warfarin
Increased anticoagulant effect, requiring INR monitoring.
Corticosteroids
Increased risk of tendon disorders.
Antacids (containing magnesium or aluminum), Sucralfate, Metal cations (iron, zinc)
Reduced oral absorption of Xelobine. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and activated charcoal may be considered. Hemodialysis is not effective in removing Xelofloxacin.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Xelofloxacin is excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent protected
Clinical Trials
Xelobine has undergone extensive Phase I, II, and III clinical trials demonstrating its efficacy and safety profile for approved indications. Ongoing post-marketing surveillance continues to monitor for rare adverse events.
Lab Monitoring
- Renal function tests (for patients with renal impairment or prolonged therapy)
- Liver function tests (for prolonged therapy or pre-existing liver conditions)
- Blood glucose levels (especially in diabetic patients)
Doctor Notes
- Emphasize to patients the importance of completing the full course of therapy.
- Counsel patients on potential serious adverse effects, especially tendinitis/tendon rupture and peripheral neuropathy, and advise immediate discontinuation if symptoms occur.
- Monitor renal function in elderly and renally impaired patients.
Patient Guidelines
- Complete the full course of Xelobine as prescribed, even if symptoms improve early.
- Stay well-hydrated during treatment.
- Avoid excessive sun exposure and use sunscreen as Xelobine can cause photosensitivity.
- Report any pain, numbness, tingling, or weakness in limbs, or signs of tendon pain/swelling immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Xelobine may cause dizziness or lightheadedness, affecting the ability to drive or operate machinery. Patients should be aware of how they react to the medication before engaging in such activities.
Lifestyle Advice
- Avoid alcohol consumption during treatment as it may exacerbate side effects.
- Inform your doctor about all medications, supplements, and herbal products you are taking.
- Do not crush or chew the tablet; swallow it whole.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.