Xelosil
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xelosil 500 mg suspension | ৳ 300.00 | N/A |
Description
Overview of the medicine
Xelosil is an oral antibiotic belonging to the third-generation cephalosporin class, used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
200 mg to 400 mg once daily, or 200 mg twice daily, depending on the severity of infection.
Elderly
No dose adjustment generally required unless renal function is severely impaired.
Renal_impairment
For creatinine clearance less than 60 mL/min, dosage adjustment is necessary. 200 mg once daily for CrCl 21-60 mL/min, and 100 mg once daily for CrCl less than 20 mL/min.
How to Take
Can be taken with or without food. For best absorption, it is often recommended to take it with food.
Mechanism of Action
Cefixime, the active ingredient in Xelosil, works by inhibiting bacterial cell wall synthesis, leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved 2-6 hours after oral administration.
Excretion
Primarily excreted unchanged in the urine (about 50%) and bile (about 10%).
Half life
Average half-life is 3-4 hours.
Absorption
Approximately 40-50% orally absorbed, food may delay absorption but not significantly affect the extent.
Metabolism
Approximately 10-15% metabolized in the liver.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity to penicillin antibiotics.
Drug Interactions
Warfarin
May increase prothrombin time; monitor INR closely.
Carbamazepine
May increase carbamazepine plasma concentrations.
Oral Contraceptives
May reduce efficacy of oral contraceptives (rarely).
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
There is no specific antidote for cefixime overdose. Gastric lavage may be indicated. Symptomatic and supportive treatment is recommended. Hemodialysis or peritoneal dialysis is not substantially effective.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Small amounts are excreted in breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Clinical trials have demonstrated Xelosil's efficacy and safety in various bacterial infections, confirming its role as a broad-spectrum antibiotic.
Lab Monitoring
- Monitor renal function (creatinine clearance) in patients with severe renal impairment.
- Periodically monitor complete blood counts (CBC) during prolonged therapy.
Doctor Notes
- Advise patients to complete the entire course of treatment to prevent the development of antibiotic resistance.
- Counsel on potential side effects, particularly diarrhea, and when to seek medical attention.
Patient Guidelines
- Complete the full course of treatment, even if you feel better.
- Do not share this medicine with others.
- Store at room temperature away from moisture and heat.
- Consult your doctor if symptoms do not improve or worsen.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Xelosil is generally not known to impair the ability to drive or operate machinery. However, if you experience dizziness or headache, avoid such activities.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid alcohol consumption during the course of treatment.
- Maintain good hygiene to prevent further infections.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.