Xenap
Generic Name
Naproxen
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xenap 500 mg tablet | ৳ 9.00 | ৳ 63.00 |
Description
Overview of the medicine
Xenap 500 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever. It is commonly prescribed for conditions like arthritis, muscle aches, menstrual cramps, and acute gout.
Uses & Indications
Dosage
Adults
For rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis: 250-500 mg orally twice daily. Max 1000 mg daily; for short-term use, up to 1250 mg for the first day, then 1000 mg/day. For acute gout: 750 mg orally once, then 250 mg every 8 hours until the attack subsides. For acute pain and dysmenorrhea: 500 mg orally once, then 250 mg every 6-8 hours as needed.
Elderly
Lower doses may be required due to increased risk of adverse effects. Initial dose of 250 mg twice daily, and monitor renal function.
Renal_impairment
Use with caution; a reduced dose may be necessary. Not recommended for severe renal impairment (creatinine clearance < 30 mL/min).
How to Take
Take Xenap 500 mg Tablet orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a full glass of water. Do not crush, chew, or break it unless specifically advised.
Mechanism of Action
Naproxen works by inhibiting the production of prostaglandins, which are chemicals in the body that cause inflammation, pain, and fever. It achieves this by blocking the cyclooxygenase (COX-1 and COX-2) enzymes.
Pharmacokinetics
Onset
Analgesic effect typically begins within 1-2 hours.
Excretion
Excreted mainly in the urine (approximately 95%) as unchanged naproxen, 6-O-desmethylnaproxen, and their conjugates. A small amount is excreted in feces.
Half life
Approximately 12-17 hours, allowing for twice-daily dosing.
Absorption
Well absorbed from the gastrointestinal tract; peak plasma concentrations reached within 2-4 hours.
Metabolism
Primarily metabolized in the liver by the cytochrome P450 system (demethylation) to 6-O-desmethylnaproxen, and both the parent drug and metabolite undergo glucuronide conjugation.
Side Effects
Contraindications
- Hypersensitivity to naproxen, aspirin, or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Drug Interactions
SSRIs
Increased risk of GI bleeding.
Lithium
May increase lithium plasma concentrations and lead to toxicity.
Methotrexate
May increase methotrexate toxicity.
Other NSAIDs and Corticosteroids
Increased risk of gastrointestinal adverse effects.
Diuretics (e.g., Furosemide) and ACE inhibitors/ARBs
May reduce the antihypertensive effect and increase the risk of renal impairment.
Anticoagulants (e.g., Warfarin) and Antiplatelets (e.g., Aspirin)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and rarely gastrointestinal bleeding. Management involves supportive and symptomatic treatment, including gastric lavage or activated charcoal if ingestion is recent. Monitor renal function and electrolyte balance.
Pregnancy & Lactation
Pregnancy: Category C during the first and second trimesters; Category D in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use should be avoided in late pregnancy. Lactation: Naproxen is excreted in breast milk. Use with caution in nursing mothers, and consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to naproxen, aspirin, or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Drug Interactions
SSRIs
Increased risk of GI bleeding.
Lithium
May increase lithium plasma concentrations and lead to toxicity.
Methotrexate
May increase methotrexate toxicity.
Other NSAIDs and Corticosteroids
Increased risk of gastrointestinal adverse effects.
Diuretics (e.g., Furosemide) and ACE inhibitors/ARBs
May reduce the antihypertensive effect and increase the risk of renal impairment.
Anticoagulants (e.g., Warfarin) and Antiplatelets (e.g., Aspirin)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and rarely gastrointestinal bleeding. Management involves supportive and symptomatic treatment, including gastric lavage or activated charcoal if ingestion is recent. Monitor renal function and electrolyte balance.
Pregnancy & Lactation
Pregnancy: Category C during the first and second trimesters; Category D in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use should be avoided in late pregnancy. Lactation: Naproxen is excreted in breast milk. Use with caution in nursing mothers, and consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date when stored correctly.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Naproxen has undergone extensive clinical trials supporting its efficacy and safety for various pain and inflammatory conditions. Ongoing research continues to explore its long-term cardiovascular and gastrointestinal safety profiles.
Lab Monitoring
- Complete blood count (CBC)
- Liver function tests (LFTs)
- Renal function tests (e.g., serum creatinine, BUN)
- Blood pressure monitoring
Doctor Notes
- Advise patients to report any signs of GI bleeding or cardiovascular symptoms immediately.
- Consider gastroprotective agents for patients at high risk of GI complications.
- Monitor renal function and blood pressure, especially in elderly or at-risk patients.
Patient Guidelines
- Always take this medicine exactly as prescribed by your doctor.
- Take with food or milk to minimize stomach upset.
- Do not exceed the recommended dose or duration of treatment.
- Avoid alcohol while taking this medicine.
- Report any unusual bleeding, persistent stomach pain, dark stools, or yellowing of the skin/eyes to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Naproxen may cause dizziness, drowsiness, or visual disturbances in some patients. If you experience these effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a healthy diet and stay hydrated.
- Engage in light exercise if appropriate for your condition.
- Limit alcohol consumption.
- Avoid smoking.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.