Xentoin
Generic Name
Xentoin
Manufacturer
PharmaCorp Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xentoin 100 mg tablet | ৳ 4.01 | N/A |
Description
Overview of the medicine
Xentoin 100 mg Tablet is an anticonvulsant medicine used to treat various types of seizures, including generalized tonic-clonic and partial seizures. It works by stabilizing electrical activity in the brain.
Uses & Indications
Dosage
Adults
Initial 100 mg three times daily, adjusted according to plasma levels and clinical response. Maintenance dose typically 300-400 mg/day in divided doses. Max 600 mg/day.
Elderly
Lower initial doses (e.g., 50 mg three times daily) and slower titration to minimize side effects.
Renal_impairment
No specific dose adjustment for mild to moderate impairment; monitor for increased side effects. Use with caution in severe impairment.
How to Take
Orally, preferably with meals to minimize gastrointestinal upset. Take at regular intervals each day.
Mechanism of Action
Stabilizes neuronal membranes and prevents the rapid spread of seizure activity by reducing repetitive firing of action potentials. It prolongs the inactive state of voltage-gated sodium channels.
Pharmacokinetics
Onset
Oral: 30-60 minutes; IV: Immediate
Excretion
Mainly renal excretion of metabolites, small amount unchanged in urine and bile.
Half life
6-24 hours (dose-dependent and individualized)
Absorption
Well absorbed from the gastrointestinal tract; bioavailability can be variable.
Metabolism
Primarily hepatic metabolism via CYP2C9 and CYP2C19 enzymes to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Xentoin or hydantoin derivatives
- History of severe dermatological reactions to Xentoin
- Severe hepatic impairment
- Bradycardia, AV block, SA block, or Stokes-Adams syndrome
Drug Interactions
Warfarin
May increase or decrease warfarin's anticoagulant effect; close monitoring of INR required.
Oral Contraceptives
May decrease the effectiveness of hormonal contraceptives, leading to unintended pregnancy.
Cimetidine, Omeprazole
May increase Xentoin levels by inhibiting its metabolism.
Carbamazepine, Phenobarbital
May decrease Xentoin levels due to enzyme induction.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nystagmus, ataxia, slurred speech, tremor, lethargy, blurred vision, nausea, vomiting, and in severe cases, coma and respiratory depression. Management is supportive, including gastric lavage or activated charcoal, and monitoring vital signs.
Pregnancy & Lactation
Pregnancy Category D: Evidence of fetal risk. Use only if potential benefit justifies potential risk to the fetus. Lactation: Excreted in breast milk; avoid breastfeeding or use with caution and monitor infant for adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved (Hypothetical)
Patent Status
Patent Expired
WHO Essential Medicine
YesClinical Trials
Ongoing phase III clinical trials are investigating Xentoin's efficacy in resistant neuropathic pain. Post-marketing surveillance studies continuously monitor safety and effectiveness in diverse populations.
Lab Monitoring
- Serum Xentoin levels (therapeutic range 10-20 mcg/mL)
- Liver function tests (ALT, AST, ALP)
- Complete blood count (CBC) with differential
- Renal function tests (BUN, Creatinine)
- Calcium and Vitamin D levels (long-term use)
Doctor Notes
- Emphasize slow dose titration to minimize adverse effects.
- Regularly monitor serum Xentoin levels, LFTs, and CBC.
- Counsel patients on adherence and the importance of not discontinuing abruptly.
- Be vigilant for signs of severe cutaneous adverse reactions.
Patient Guidelines
- Do not stop taking Xentoin abruptly, as this can lead to an increase in seizure frequency or status epilepticus.
- Report any skin rash, fever, swollen lymph nodes, or mouth sores to your doctor immediately.
- Maintain good oral hygiene to prevent gingival hyperplasia.
- Regular dental check-ups are recommended.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Xentoin may cause dizziness, drowsiness, or blurred vision. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid excessive alcohol consumption.
- Ensure adequate intake of calcium and Vitamin D, especially with long-term use.
- Maintain a balanced diet and regular sleep schedule.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.