Xevlin
Generic Name
Xevofloxacin 500 mg Tablet
Manufacturer
MediGen Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xevlin 500 mg tablet | ৳ 55.00 | ৳ 330.00 |
Description
Overview of the medicine
Xevlin 500 mg Tablet contains Xevofloxacin, a broad-spectrum fluoroquinolone antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
Typically 500 mg once daily for 7-14 days, depending on the infection.
Elderly
No specific dose adjustment is usually required unless severe renal impairment is present.
Renal_impairment
Dose adjustment required based on creatinine clearance (e.g., 250 mg once daily for CrCl < 50 mL/min).
How to Take
Take orally with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Xevofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Within 1-2 hours
Excretion
Primarily excreted unchanged by the kidneys.
Half life
Approximately 7-9 hours
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract.
Metabolism
Minimally metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Xevofloxacin or other fluoroquinolones
- History of tendon disorders related to fluoroquinolone administration
Drug Interactions
NSAIDs
May increase the risk of CNS stimulation and convulsions.
Warfarin
Increased anticoagulant effects. Monitor INR closely.
Corticosteroids
Increased risk of tendon rupture.
Antacids (containing magnesium/aluminum)
Decreased absorption of Xevofloxacin. Take Xevlin at least 2 hours before or 4 hours after antacids.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, abdominal pain, dizziness, confusion, and convulsions. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Use in pregnancy only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding as Xevofloxacin is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved (DGDA)
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated Xevofloxacin's efficacy and safety in various bacterial infections, with specific studies focusing on its use in respiratory and urinary tract infections.
Lab Monitoring
- Renal function tests (for patients with impaired renal function)
- Liver function tests (if signs of hepatotoxicity develop)
- Blood glucose (for diabetic patients)
Doctor Notes
- Advise patients to report any tendon pain or swelling immediately.
- Counsel on the importance of completing the full course.
- Be aware of potential interactions with antacids and warfarin.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve.
- Stay well-hydrated during treatment.
- Avoid excessive sun exposure due to photosensitivity.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double dose.
Driving Precautions
May cause dizziness or lightheadedness; caution advised when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Report any unusual joint pain or swelling immediately.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.