Xiamin
Generic Name
Xiamoxacin
Manufacturer
Global Pharma Inc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xiamin 750 mg tablet | ৳ 15.00 | ৳ 90.00 |
Description
Overview of the medicine
Xiamin 750 mg Tablet contains Xiamoxacin, a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
750 mg once daily for 5-14 days, depending on the type and severity of infection.
Elderly
No specific dose adjustment required for elderly patients unless severe renal impairment is present.
Renal_impairment
For creatinine clearance < 30 mL/min, dose adjustment to 375 mg once daily is recommended.
How to Take
Orally, with or without food. Should be swallowed whole with water. Do not crush or chew the tablet.
Mechanism of Action
Xiamoxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Within 1-2 hours
Excretion
Mainly renal excretion (approximately 60-70% unchanged drug in urine), with some fecal excretion.
Half life
Approximately 6-8 hours
Absorption
Rapidly and extensively absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Primarily hepatic metabolism, with some active and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Xiamoxacin or any other fluoroquinolone antibiotic.
- History of tendinitis or tendon rupture associated with fluoroquinolone use.
- Patients with myasthenia gravis.
Drug Interactions
Warfarin
Increased anticoagulant effect, leading to increased bleeding risk. INR monitoring is recommended.
Antacids, Iron, Zinc supplements
May reduce the absorption of Xiamoxacin. Take Xiamoxacin at least 2 hours before or 6 hours after these agents.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of CNS stimulation and convulsive seizures.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, symptomatic and supportive care should be initiated. Gastric lavage may be considered if ingestion is recent. Monitor ECG and vital signs.
Pregnancy & Lactation
Xiamoxacin is generally not recommended during pregnancy or lactation due to potential adverse effects on fetal/infant cartilage development. Use only if the potential benefit justifies the potential risk.
Side Effects
Contraindications
- Hypersensitivity to Xiamoxacin or any other fluoroquinolone antibiotic.
- History of tendinitis or tendon rupture associated with fluoroquinolone use.
- Patients with myasthenia gravis.
Drug Interactions
Warfarin
Increased anticoagulant effect, leading to increased bleeding risk. INR monitoring is recommended.
Antacids, Iron, Zinc supplements
May reduce the absorption of Xiamoxacin. Take Xiamoxacin at least 2 hours before or 6 hours after these agents.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of CNS stimulation and convulsive seizures.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, symptomatic and supportive care should be initiated. Gastric lavage may be considered if ingestion is recent. Monitor ECG and vital signs.
Pregnancy & Lactation
Xiamoxacin is generally not recommended during pregnancy or lactation due to potential adverse effects on fetal/infant cartilage development. Use only if the potential benefit justifies the potential risk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by relevant authorities (e.g., DGDA)
Patent Status
Patent protected
Clinical Trials
Successfully completed Phase III clinical trials, demonstrating significant efficacy and safety in various bacterial infection models.
Lab Monitoring
- Renal function (creatinine clearance) before and during treatment.
- Liver function tests (LFTs) if prolonged treatment or liver impairment is suspected.
- Complete blood count (CBC) occasionally.
Doctor Notes
- Counsel patients thoroughly on potential serious adverse reactions, especially tendinitis/tendon rupture and neurological effects.
- Ensure appropriate renal dose adjustment in patients with impaired kidney function.
- Emphasize the importance of completing the full prescribed course to minimize resistance development.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if you feel better.
- Avoid excessive sun exposure and use protective clothing/sunscreen due to photosensitivity.
- Report any joint pain, swelling, muscle weakness, numbness, or tingling immediately to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take two doses at once to make up for a missed dose.
Driving Precautions
This medicine may cause dizziness or visual disturbances. Exercise caution when driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid alcohol consumption during the treatment period.
- Do not take dairy products or calcium-fortified juices within 2 hours of taking Xiamin 750 mg Tablet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.