Xicotil
Generic Name
Piroxicam
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xicotil 20 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Xicotil 20 mg Tablet contains Piroxicam, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and stiffness caused by various conditions like arthritis.
Uses & Indications
Dosage
Adults
Usually 20 mg once daily, or 10 mg twice daily. For acute musculoskeletal disorders, 40 mg once daily for the first 2 days, then 20 mg once daily for 7-14 days. Lowest effective dose for shortest duration is recommended.
Elderly
Use with caution; lower doses may be required due to increased risk of adverse effects.
Renal_impairment
Use with caution; dosage adjustment may be necessary. Not recommended for severe renal impairment.
How to Take
Take orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Piroxicam inhibits prostaglandin synthesis by reversibly inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. This reduces inflammation, pain, and fever.
Pharmacokinetics
Onset
Analgesic effect usually within 30-60 minutes.
Excretion
Excreted mainly in the urine (as metabolites) and a lesser extent in the feces.
Half life
Approximately 50-60 hours.
Absorption
Well absorbed from the gastrointestinal tract; peak plasma concentrations reached in 3-5 hours.
Metabolism
Extensively metabolized in the liver, primarily by hydroxylation of the pyridyl ring.
Side Effects
Contraindications
- •Hypersensitivity to Piroxicam or other NSAIDs
- •Active gastrointestinal bleeding or peptic ulcer
- •Severe heart failure
- •Severe renal or hepatic impairment
- •Third trimester of pregnancy
- •Concomitant use with other NSAIDs or anticoagulants
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Other NSAIDs and Corticosteroids
Increased risk of gastrointestinal adverse effects.
Antiplatelet agents (e.g., Aspirin)
Increased risk of gastrointestinal bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to risk of premature closure of fetal ductus arteriosus. Use with caution during early pregnancy and lactation only if clearly needed and benefits outweigh risks. Piroxicam is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Generic available (Patent expired)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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