Xidolac
Generic Name
Ketorolac Tromethamine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xidolac 10 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Xidolac 10 mg Tablet contains Ketorolac Tromethamine, a non-steroidal anti-inflammatory drug (NSAID) used for short-term management of moderately severe acute pain that requires analgesia at the opioid level, typically post-operative pain.
Uses & Indications
Dosage
Adults
Initially 10 mg orally every 4-6 hours as needed, not exceeding 40 mg/day. Treatment duration should not exceed 5 days.
Elderly
Lower doses (e.g., 5 mg every 6 hours) are recommended due to increased risk of side effects, not exceeding 20 mg/day. Max 5 days.
Renal_impairment
Contraindicated in severe renal impairment. In moderate impairment, dosage reduction is required; maximum 10 mg every 6-8 hours, not exceeding 30 mg/day. Max 5 days.
How to Take
Oral tablet should be taken with food or milk to minimize gastrointestinal upset. Do not crush or chew.
Mechanism of Action
Inhibits prostaglandin synthesis by non-selectively inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing inflammation, pain, and fever.
Pharmacokinetics
Onset
Approximately 30-60 minutes after oral administration.
Excretion
Mainly renal (about 91%) with some fecal excretion (about 6%).
Half life
Approximately 4-6 hours (ranges 2-9 hours).
Absorption
Rapidly and completely absorbed orally, peak plasma concentrations reached within 30-60 minutes.
Metabolism
Primarily hepatic, mainly by glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to ketorolac, aspirin, or other NSAIDs.
- Active peptic ulcer, recent gastrointestinal bleeding or perforation, history of GI bleeding.
- Advanced renal impairment.
- Peri-operative pain in coronary artery bypass graft (CABG) surgery.
- Concomitant use with other NSAIDs, aspirin, anticoagulants, or probenecid.
- Pregnancy (especially third trimester) and lactation.
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Diuretics
Reduced diuretic effect.
Methotrexate
Increased methotrexate toxicity.
ACE inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Other NSAIDs/Aspirin
Increased risk of GI side effects.
Anticoagulants (Warfarin, Heparin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include abdominal pain, nausea, vomiting, lethargy. Gastric lavage, activated charcoal, and symptomatic supportive care should be provided. No specific antidote.
Pregnancy & Lactation
Contraindicated in pregnancy (especially third trimester due to risk of premature closure of ductus arteriosus) and lactation (secreted in breast milk).
Side Effects
Contraindications
- Hypersensitivity to ketorolac, aspirin, or other NSAIDs.
- Active peptic ulcer, recent gastrointestinal bleeding or perforation, history of GI bleeding.
- Advanced renal impairment.
- Peri-operative pain in coronary artery bypass graft (CABG) surgery.
- Concomitant use with other NSAIDs, aspirin, anticoagulants, or probenecid.
- Pregnancy (especially third trimester) and lactation.
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Diuretics
Reduced diuretic effect.
Methotrexate
Increased methotrexate toxicity.
ACE inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Other NSAIDs/Aspirin
Increased risk of GI side effects.
Anticoagulants (Warfarin, Heparin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include abdominal pain, nausea, vomiting, lethargy. Gastric lavage, activated charcoal, and symptomatic supportive care should be provided. No specific antidote.
Pregnancy & Lactation
Contraindicated in pregnancy (especially third trimester due to risk of premature closure of ductus arteriosus) and lactation (secreted in breast milk).
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved for short-term pain management
Patent Status
Generic available
Clinical Trials
Extensively studied for post-operative pain management and various acute pain conditions, demonstrating efficacy comparable to opioids but with different safety profiles.
Lab Monitoring
- Renal function (creatinine, BUN) – especially in elderly or those with pre-existing impairment.
- Liver function tests (ALT, AST) – periodically for prolonged use, or if symptoms suggest liver dysfunction.
- Complete blood count (CBC) – for signs of bleeding.
Doctor Notes
- Emphasize short-term use only (max 5 days) and proper patient selection, especially regarding GI, renal, and cardiovascular risk factors.
- Monitor renal function, especially in elderly or dehydrated patients.
- Co-administration with anticoagulants, other NSAIDs, or systemic corticosteroids should be avoided or carefully managed.
Patient Guidelines
- Do not exceed the recommended dose or duration of treatment (maximum 5 days).
- Take with food or milk to reduce stomach upset.
- Report any signs of stomach pain, black stools, or unusual bleeding/bruising immediately.
- Avoid alcohol during treatment as it may increase the risk of stomach bleeding.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or drowsiness. Avoid driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Avoid other NSAIDs or aspirin while taking Xidolac unless advised by a doctor.
- Stay hydrated, especially if you experience kidney-related concerns.
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