Xinarox-CV
Generic Name
Cefuroxime Axetil + Potassium Clavulanate
Manufacturer
Leading Pharma Inc.
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xinarox cv 500 mg tablet | ৳ 55.00 | ৳ 220.00 |
Description
Overview of the medicine
Xinarox-CV 500 mg Tablet is a combination antibiotic containing Cefuroxime and Clavulanic Acid. It is used to treat a wide range of bacterial infections, including those caused by beta-lactamase producing strains.
Uses & Indications
Dosage
Adults
One tablet (Cefuroxime 500 mg/Clavulanic Acid 125 mg) twice daily, or as directed by the physician. Duration of treatment varies depending on the infection.
Elderly
Similar to adult dosage, but renal function should be considered and dosage adjusted if necessary.
Renal_impairment
Dosage adjustment is required based on creatinine clearance. For patients with creatinine clearance <30 mL/min, dosage intervals should be extended.
How to Take
Take orally, preferably with food to optimize absorption. Tablets should not be crushed or chewed.
Mechanism of Action
Cefuroxime inhibits bacterial cell wall synthesis. Clavulanic acid is a beta-lactamase inhibitor that protects cefuroxime from degradation by beta-lactamase enzymes, thereby extending its antibacterial spectrum.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved within 1-3 hours after oral administration.
Excretion
Cefuroxime is excreted unchanged primarily by the kidneys via glomerular filtration and tubular secretion. Clavulanate is excreted via urine, mainly as metabolites, and some unchanged drug.
Half life
The plasma half-life for cefuroxime is approximately 1.2-1.5 hours and for clavulanate is approximately 1 hour.
Absorption
Cefuroxime axetil is absorbed from the gastrointestinal tract and rapidly hydrolyzed in the intestinal mucosa and blood to release cefuroxime. Clavulanate is also well absorbed orally.
Metabolism
Cefuroxime is not significantly metabolized in the body. Clavulanate is extensively metabolized.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, clavulanic acid, or any component of the formulation.
- Patients with a history of severe hypersensitivity (e.g., anaphylaxis) to any other beta-lactam antibacterial agents (e.g., penicillins, carbapenems, monobactams).
Drug Interactions
Probenecid
Concomitant use with probenecid increases the area under the serum concentration versus time curve of cefuroxime.
Aminoglycosides
Although uncommon, concurrent use with aminoglycosides may increase the risk of nephrotoxicity.
Oral Contraceptives
May reduce the efficacy of oral contraceptives (though clinical significance is generally not established for most antibiotics).
Antacids/H2 blockers/PPIs
Drugs that reduce gastric acidity may result in lower bioavailability of cefuroxime axetil and should be avoided or administered several hours apart.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms include gastrointestinal disturbances and convulsions. Management is supportive and symptomatic. Hemodialysis can reduce serum levels of cefuroxime and clavulanic acid.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, use in pregnancy only if clearly needed. Cefuroxime and clavulanic acid are excreted in breast milk in small amounts; use with caution in lactating women, monitoring for infant side effects like diarrhea or candidiasis.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, clavulanic acid, or any component of the formulation.
- Patients with a history of severe hypersensitivity (e.g., anaphylaxis) to any other beta-lactam antibacterial agents (e.g., penicillins, carbapenems, monobactams).
Drug Interactions
Probenecid
Concomitant use with probenecid increases the area under the serum concentration versus time curve of cefuroxime.
Aminoglycosides
Although uncommon, concurrent use with aminoglycosides may increase the risk of nephrotoxicity.
Oral Contraceptives
May reduce the efficacy of oral contraceptives (though clinical significance is generally not established for most antibiotics).
Antacids/H2 blockers/PPIs
Drugs that reduce gastric acidity may result in lower bioavailability of cefuroxime axetil and should be avoided or administered several hours apart.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms include gastrointestinal disturbances and convulsions. Management is supportive and symptomatic. Hemodialysis can reduce serum levels of cefuroxime and clavulanic acid.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, use in pregnancy only if clearly needed. Cefuroxime and clavulanic acid are excreted in breast milk in small amounts; use with caution in lactating women, monitoring for infant side effects like diarrhea or candidiasis.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Ongoing post-marketing surveillance and clinical studies to evaluate efficacy against evolving bacterial resistance patterns and for new indications.
Lab Monitoring
- Periodical assessment of renal function (especially in patients with pre-existing renal impairment or on prolonged therapy).
- Liver function tests may be monitored occasionally.
Doctor Notes
- Emphasize the importance of completing the full course of therapy to ensure eradication of infection and prevent resistance.
- Adjust dosage in patients with significant renal impairment.
- Be aware of the potential for Clostridium difficile-associated diarrhea, even several weeks after discontinuation of therapy.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve to prevent antibiotic resistance.
- Take the medicine with food to enhance absorption and reduce gastrointestinal upset.
- Do not share your medication with others, even if they have similar symptoms.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness. Patients should be cautious when driving or operating machinery until they know how Xinarox-CV affects them.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid alcohol, especially if it exacerbates gastrointestinal side effects.
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