Xoferon
Generic Name
xoferon-100-mg-injection
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xoferon 100 mg injection | ৳ 325.98 | N/A |
Description
Overview of the medicine
Xoferon 100 mg Injection is an intravenous iron preparation containing iron sucrose, used for the treatment of iron deficiency anemia in patients undergoing hemodialysis who are receiving erythropoietin therapy, and for non-dialysis dependent chronic kidney disease patients.
Uses & Indications
Dosage
Adults
Usually 100 mg (5 mL) administered intravenously as a slow injection over 2-5 minutes or infused over 15-30 minutes, 1-3 times a week, up to a cumulative dose of 1000 mg (10 doses). Dose and frequency adjusted based on patient's iron status and response.
Elderly
No specific dose adjustment required for elderly patients, but caution is advised due to potential for comorbidities and polypharmacy.
Renal_impairment
Used in patients with chronic kidney disease; dosage is as specified in indications.
How to Take
Administered intravenously, either by slow injection (over 2-5 minutes) or by infusion (diluted in normal saline, over 15-30 minutes or longer for higher doses). Must not be administered intramuscularly or subcutaneously.
Mechanism of Action
Iron sucrose complex is dissociated by the reticuloendothelial system into iron and sucrose. Iron is then transported by transferrin to the bone marrow for erythropoiesis, or stored in the liver as ferritin. It replenishes iron stores necessary for hemoglobin synthesis.
Pharmacokinetics
Onset
Hemoglobin response usually observed within weeks.
Excretion
Renal excretion of sucrose and minimal iron; iron is mostly utilized or stored.
Half life
The iron component has a half-life of 3-4 hours after administration. The sucrose component is rapidly eliminated.
Absorption
Administered intravenously, so bioavailability is 100%. Iron is taken up by reticuloendothelial cells.
Metabolism
Iron is metabolized within the reticuloendothelial system. Sucrose is largely cleared.
Side Effects
Contraindications
- Hypersensitivity to iron sucrose or any of its components.
- Anemia not caused by iron deficiency.
- Iron overload or disturbances in iron utilization (e.g., hemochromatosis, hemosiderosis).
- First trimester of pregnancy.
Drug Interactions
Oral iron preparations
Reduced absorption of oral iron preparations when administered concomitantly.
Angiotensin-converting enzyme (ACE) inhibitors
Increased risk of hypotension with concomitant use in some cases.
Storage
Store at controlled room temperature (20-25°C), excursions permitted to 15-30°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
Overdose can lead to acute iron overload, which may manifest as hypotension, collapse, nausea, vomiting, abdominal pain, diarrhea. Long-term overdose can lead to hemosiderosis. Treatment involves supportive care and iron chelating agents (e.g., deferoxamine) if severe.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Avoid during the first trimester. Limited data on excretion in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to iron sucrose or any of its components.
- Anemia not caused by iron deficiency.
- Iron overload or disturbances in iron utilization (e.g., hemochromatosis, hemosiderosis).
- First trimester of pregnancy.
Drug Interactions
Oral iron preparations
Reduced absorption of oral iron preparations when administered concomitantly.
Angiotensin-converting enzyme (ACE) inhibitors
Increased risk of hypotension with concomitant use in some cases.
Storage
Store at controlled room temperature (20-25°C), excursions permitted to 15-30°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
Overdose can lead to acute iron overload, which may manifest as hypotension, collapse, nausea, vomiting, abdominal pain, diarrhea. Long-term overdose can lead to hemosiderosis. Treatment involves supportive care and iron chelating agents (e.g., deferoxamine) if severe.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Avoid during the first trimester. Limited data on excretion in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years, as specified on the package label when stored according to recommendations.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of iron sucrose in treating iron deficiency anemia in CKD patients, leading to its global approval.
Lab Monitoring
- Hemoglobin and hematocrit levels
- Serum ferritin and transferrin saturation (TSAT) before initiation and periodically during treatment.
- Blood pressure and heart rate during and after administration.
Doctor Notes
- Monitor patient for signs of hypersensitivity reactions for at least 30 minutes after each administration.
- Administer cautiously in patients with active bacterial infection.
- Regularly monitor hemoglobin, serum ferritin, and TSAT to avoid iron overload.
- Adjust dose based on patient's individual iron requirements and response.
Patient Guidelines
- Inform your doctor about all existing medical conditions, especially liver or kidney disease, or allergies.
- Report any discomfort or adverse reactions during or after the injection immediately.
- Do not take oral iron supplements unless advised by your doctor, as this medicine is intravenous.
- Follow your doctor's instructions regarding diet and other medications.
Missed Dose Advice
Contact your doctor or nurse if you miss a dose. Do not take a double dose to make up for a missed dose.
Driving Precautions
This medicine may cause dizziness or lightheadedness, especially after administration. Patients should be advised not to drive or operate machinery until they know how the medicine affects them.
Lifestyle Advice
- Maintain a balanced diet rich in iron-containing foods, if appropriate for your condition.
- Stay hydrated.
- Regular follow-ups with your doctor are crucial to monitor your iron levels and overall health.
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Global Brand Names
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