Xolmel
Generic Name
Synthetic Anxiolytic
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xolmel 05 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Xolmel 0.5 mg Tablet is a medication primarily used for the short-term relief of anxiety symptoms. It belongs to a class of drugs that enhance the effect of a certain natural chemical in the body (GABA), which calms brain activity.
Uses & Indications
Dosage
Adults
Initial dose 0.25-0.5 mg three times daily. May be increased up to 4 mg daily in divided doses based on response.
Elderly
Initial dose 0.25 mg two to three times daily. Dose adjustments should be made cautiously due to increased sensitivity.
Renal_impairment
No specific dose adjustment guidelines; use with caution. Consider lower starting doses.
How to Take
Take orally with or without food. Do not crush, chew, or break the tablet. Swallow whole.
Mechanism of Action
Xolmel acts by binding to specific sites on the GABA-A receptors in the brain, thereby enhancing the inhibitory effects of GABA. This leads to decreased neuronal excitability and produces anxiolytic, sedative, and muscle relaxant effects.
Pharmacokinetics
Onset
Approximately 30-60 minutes.
Excretion
Excreted mainly via the kidneys as metabolites.
Half life
Elimination half-life ranges from 8 to 12 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver by cytochrome P450 3A4 (CYP3A4) enzymes into inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to Xolmel or other benzodiazepines
- •Acute narrow-angle glaucoma
- •Severe respiratory insufficiency
- •Sleep apnea
Drug Interactions
Opioids
Increased risk of profound sedation, respiratory depression, coma, and death.
Fluvoxamine, Nefazodone
Moderate CYP3A4 inhibitors, increase Xolmel concentrations.
Ketoconazole, Itraconazole
Potent CYP3A4 inhibitors, significantly increase Xolmel plasma concentrations.
Alcohol and other CNS depressants
Additive CNS depressant effects, increasing risk of drowsiness and sedation.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, impaired coordination, diminished reflexes, and coma. Management is primarily supportive; maintain airway, monitor vital signs. Flumazenil may be considered in severe cases, but caution is advised due to potential for withdrawal symptoms or seizures.
Pregnancy & Lactation
Xolmel is not recommended during pregnancy, especially during the first trimester, due to potential risk of congenital malformations. It is excreted in breast milk and may cause sedation in the infant; therefore, use is generally not recommended during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Pending
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Global Brand Names
International brand names for this medicine
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