Xpain
Generic Name
Etodolac
Manufacturer
MediPrime Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xpain 100 mg tablet | ৳ 3.01 | ৳ 30.10 |
Description
Overview of the medicine
Xpain 100 mg Tablet contains Etodolac, a non-steroidal anti-inflammatory drug (NSAID), used for the relief of pain, inflammation, and stiffness caused by various conditions such as osteoarthritis, rheumatoid arthritis, and acute pain.
Uses & Indications
Dosage
Adults
Typically 100-200 mg twice daily, or as directed by a physician. Maximum daily dose should not exceed 1000 mg.
Elderly
Lower doses may be required, closely monitored for adverse effects.
Renal_impairment
Dosage adjustment is necessary. Start with lower doses and monitor renal function.
How to Take
Taken orally with food or milk to minimize gastrointestinal upset.
Mechanism of Action
Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, leading to reduced prostaglandin synthesis, thereby exerting anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics
Onset
Pain relief usually starts within 30-60 minutes.
Excretion
Primarily excreted in the urine as metabolites, with a small amount excreted in feces.
Half life
Approximately 6-7 hours.
Absorption
Well absorbed from the gastrointestinal tract, with peak plasma concentrations reached in 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily via glucuronidation and hydroxylation.
Side Effects
Contraindications
- Hypersensitivity to Etodolac or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased lithium plasma levels.
Warfarin
Increased risk of bleeding.
ACE inhibitors / Diuretics
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves supportive care and symptomatic treatment. Gastric lavage or activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use with caution during earlier trimesters and during lactation, only if clearly needed and benefits outweigh risks.
Side Effects
Contraindications
- Hypersensitivity to Etodolac or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased lithium plasma levels.
Warfarin
Increased risk of bleeding.
ACE inhibitors / Diuretics
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves supportive care and symptomatic treatment. Gastric lavage or activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use with caution during earlier trimesters and during lactation, only if clearly needed and benefits outweigh risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety in patients with osteoarthritis, rheumatoid arthritis, and acute pain.
Lab Monitoring
- Complete blood count (CBC)
- Renal function tests (Creatinine, BUN)
- Liver function tests (ALT, AST)
- Blood pressure monitoring
Doctor Notes
- Advise patients to report any unusual bleeding or bruising.
- Monitor renal and hepatic function during prolonged therapy.
- Caution in patients with a history of hypertension or heart failure.
Patient Guidelines
- Take with food or milk to reduce stomach upset.
- Do not exceed the prescribed dose.
- Inform your doctor about all other medications you are taking.
- Report any signs of stomach bleeding (e.g., black, tarry stools).
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness; caution is advised when driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption while on this medication.
- Maintain a healthy diet and stay hydrated.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.