Xtrafen
Generic Name
Xylotifen Sodium 100 mg Tablet
Manufacturer
MediCorp Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xtrafen 100 mg tablet | ৳ 2.00 | ৳ 20.00 |
Description
Overview of the medicine
Xtrafen-100 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of mild to moderate pain, inflammation, and fever.
Uses & Indications
Dosage
Adults
100 mg orally, 1-2 times daily, with food or milk.
Elderly
Lower initial dose may be considered, carefully monitor for side effects.
Renal_impairment
Use with caution; dose adjustment may be necessary based on creatinine clearance.
How to Take
Take orally with a glass of water, preferably after meals to minimize gastrointestinal upset.
Mechanism of Action
Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, leading to reduced prostaglandin synthesis and thus reducing inflammation, pain, and fever.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Mainly excreted in urine, with a small portion excreted in feces.
Half life
Approximately 2-4 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver via cytochrome P450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Xylotifen or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE Inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptoms may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves supportive and symptomatic treatment, including gastric lavage or activated charcoal.
Pregnancy & Lactation
Category C in pregnancy (avoid in third trimester). Not recommended during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Xylotifen or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE Inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptoms may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves supportive and symptomatic treatment, including gastric lavage or activated charcoal.
Pregnancy & Lactation
Category C in pregnancy (avoid in third trimester). Not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies and Hospitals
Approval Status
Approved by regulatory bodies
Patent Status
Patent Pending
Clinical Trials
Ongoing Phase III trials for long-term efficacy and safety in chronic pain management.
Lab Monitoring
- Complete Blood Count (CBC)
- Liver Function Tests (LFTs)
- Renal Function Tests (RFTs)
Doctor Notes
- Advise patients to report any unusual bleeding or stomach pain.
- Regular monitoring of renal and hepatic function is recommended during prolonged therapy.
Patient Guidelines
- Take with food to reduce stomach irritation.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Report any signs of gastrointestinal bleeding immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness; avoid driving or operating machinery if affected.
Lifestyle Advice
- Avoid alcohol consumption.
- Maintain a healthy diet and stay hydrated.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.