Xynofen-SR
Generic Name
Xynofen (as Diclofenac Sodium equivalent) 100 mg
Manufacturer
Reputable Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xynofen sr 100 mg capsule | ৳ 7.54 | ৳ 75.40 |
Description
Overview of the medicine
Xynofen-SR 100 mg capsule is a sustained-release non-steroidal anti-inflammatory drug (NSAID) used for the long-term treatment of chronic inflammatory conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis, as well as for pain management.
Uses & Indications
Dosage
Adults
100 mg once daily, preferably after a meal. Max dose 100 mg/day for long-term use.
Elderly
Start with the lowest effective dose and monitor for adverse effects, especially gastrointestinal bleeding.
Renal_impairment
Use with caution; dose reduction may be required for severe impairment. Not recommended for severe renal disease (CrCl < 30 mL/min).
How to Take
Swallow the capsule whole with water after a meal. Do not chew, crush, or break the capsule.
Mechanism of Action
Xynofen-SR exerts its anti-inflammatory, analgesic, and antipyretic effects primarily through the inhibition of prostaglandin synthesis by reversibly inhibiting cyclooxygenase (COX-1 and COX-2) enzymes. The sustained-release formulation ensures prolonged therapeutic effect.
Pharmacokinetics
Onset
Onset of action is typically within 1-2 hours, with full anti-inflammatory effect taking several days.
Excretion
About 60% excreted in the urine as metabolites, and about 30% in the bile and feces.
Half life
Elimination half-life is approximately 1.5-2 hours for the active compound, but the sustained-release profile extends its effective duration significantly.
Absorption
Well absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 4-8 hours due to the sustained-release nature.
Metabolism
Extensively metabolized in the liver, primarily by hydroxylation and subsequent glucuronidation. Metabolites are pharmacologically less active.
Side Effects
Contraindications
- Hypersensitivity to Xynofen or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe hepatic or renal impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, nausea, vomiting, epigastric pain, GI bleeding, hypotension, respiratory depression, and coma. Management is supportive, including gastric lavage, activated charcoal, and symptomatic treatment.
Pregnancy & Lactation
Category C in first two trimesters, Category D in third trimester (due to risk of premature closure of ductus arteriosus). Avoid during lactation.
Side Effects
Contraindications
- Hypersensitivity to Xynofen or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe hepatic or renal impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, nausea, vomiting, epigastric pain, GI bleeding, hypotension, respiratory depression, and coma. Management is supportive, including gastric lavage, activated charcoal, and symptomatic treatment.
Pregnancy & Lactation
Category C in first two trimesters, Category D in third trimester (due to risk of premature closure of ductus arteriosus). Avoid during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Clinical trials demonstrate efficacy and safety in chronic inflammatory conditions, showing sustained pain relief and improved functional outcomes compared to immediate-release formulations.
Lab Monitoring
- Complete Blood Count (CBC) (for long-term use)
- Liver function tests
- Kidney function tests (Serum Creatinine, eGFR)
Doctor Notes
- Advise patients to take with food to minimize GI upset.
- Monitor renal and hepatic function, especially in elderly or patients with pre-existing conditions.
- Educate on symptoms of GI bleeding and cardiovascular events.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Report any signs of stomach pain, black stools, or unusual bleeding immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances; use caution when driving or operating machinery.
Lifestyle Advice
- Avoid alcohol during treatment.
- Maintain a healthy diet and stay hydrated.
- Consult your doctor before taking any other pain relievers.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.