Xytrex
Generic Name
Xytreline Hydrochloride
Manufacturer
MediCorp Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xytrex 5 mg tablet | ৳ 2.52 | ৳ 25.20 |
Description
Overview of the medicine
Xytrex 5 mg Tablet is an anxiolytic medication used to treat generalized anxiety disorder and panic disorder. It works by affecting certain chemicals in the brain to reduce feelings of anxiety and fear.
Uses & Indications
Dosage
Adults
Initial dose: 5 mg once daily. May be increased to 10 mg or 20 mg daily, divided into two doses, after 1 week based on response and tolerability. Max dose: 30 mg/day.
Elderly
Initial dose: 2.5 mg once daily. Titrate cautiously to desired effect. Max dose: 15 mg/day.
Renal_impairment
Mild to moderate impairment: No dose adjustment needed. Severe impairment: Use with caution, consider reduced dose (e.g., 2.5 mg once daily).
How to Take
Take orally with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Xytreline acts as a partial agonist at serotonin 5-HT1A receptors in the brain. This action modulates serotonin neurotransmission, leading to anxiolytic effects without causing significant sedation, muscle relaxation, or cognitive impairment typically associated with benzodiazepines.
Pharmacokinetics
Onset
Initial anxiolytic effects within 1-2 weeks; full therapeutic effects seen after 4-6 weeks of consistent use.
Excretion
Mainly excreted via urine (60-70%) and feces (30-40%) as metabolites.
Half life
Approximately 10-14 hours (terminal half-life).
Absorption
Well absorbed orally; bioavailability is about 90%. Peak plasma concentrations reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to xytreline or any components of the tablet.
- Concomitant use with MAO inhibitors.
- Severe hepatic impairment.
Drug Interactions
Alcohol
Additive CNS depressant effects possible, use with caution.
MAO Inhibitors
Increased risk of serotonin syndrome. Concomitant use is contraindicated.
Strong CYP3A4 Inducers (e.g., rifampin, carbamazepine)
May decrease xytreline plasma levels, reducing efficacy.
Strong CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir)
May increase xytreline plasma levels, requiring dose reduction.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, dizziness, nausea, and vomiting. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk to fetus. Excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Under patent protection
Clinical Trials
Extensive Phase I, II, and III clinical trials demonstrated efficacy and safety in generalized anxiety disorder patients, showing superior anxiolytic effects compared to placebo and comparable safety to existing therapies.
Lab Monitoring
- No specific routine lab monitoring required. Monitor liver function in patients with pre-existing hepatic impairment.
Doctor Notes
- Advise patients that full therapeutic effect may take several weeks.
- Counsel on the importance of gradual discontinuation to avoid withdrawal symptoms.
- Monitor for potential drug interactions, especially with CYP3A4 inhibitors/inducers.
Patient Guidelines
- Take Xytrex regularly as prescribed by your doctor, even if you feel better.
- Do not stop taking Xytrex abruptly, as this may lead to withdrawal symptoms. Consult your doctor for gradual dose reduction.
- Avoid alcohol while taking this medication.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue your regular schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Xytrex may cause dizziness or drowsiness, especially at the beginning of treatment. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Engage in regular exercise.
- Practice relaxation techniques like meditation or yoga.
- Maintain a balanced diet and adequate sleep.
- Limit caffeine intake.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.