Lidocaine 2% Gel (Generic)
Generic Name
Lidocaine Hydrochloride 2% Gel
Manufacturer
Various Generic Manufacturers
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| z lidocaine 2 gel | ৳ 100.00 | N/A |
Description
Overview of the medicine
Lidocaine 2% Gel is a topical local anesthetic used to numb an area of the body to relieve pain, itching, or discomfort caused by minor skin irritations, insect bites, or for surface anesthesia of mucous membranes prior to minor procedures.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected area as needed, typically up to 3-4 times daily. The maximum recommended dose varies by body area and specific procedure; consult product leaflet or healthcare professional.
Elderly
Similar to adults, but use with caution and adjust dose if signs of systemic toxicity appear, especially in frail patients or those with reduced hepatic/renal function.
Renal_impairment
No specific dosage adjustment recommended for topical application as systemic absorption is minimal. However, caution should be exercised in severe cases if significant systemic absorption is anticipated.
How to Take
For topical application to skin or mucous membranes. Apply a thin film to the affected area. Do not ingest. Wash hands immediately after use.
Mechanism of Action
Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby affecting local anesthetic action. It blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions.
Pharmacokinetics
Onset
2-5 minutes (topical).
Excretion
Mainly via the kidneys, with less than 10% excreted as unchanged drug.
Half life
Approximately 1.5-2 hours (systemic).
Absorption
Systemic absorption varies with the integrity of the skin/mucous membrane, dose, and duration of application. Minimal absorption from intact skin. Rapidly absorbed from mucous membranes.
Metabolism
Primarily hepatic (by CYP1A2 and CYP3A4) to active and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to lidocaine or other amide-type local anesthetics.
- Application to large areas of broken or severely traumatized skin, as this increases the risk of systemic absorption and toxicity.
Drug Interactions
Other Local Anesthetics
Concurrent use may lead to additive systemic effects, increasing the risk of toxicity.
Antiarrhythmic Drugs (e.g., Mexiletine, Amiodarone)
Caution with concomitant use, especially if significant systemic absorption of lidocaine occurs, due to potential for additive cardiac effects.
Storage
Store below 25°C. Protect from light and moisture. Do not freeze. Keep out of sight and reach of children.
Overdose
Systemic overdose is rare with proper topical application. Symptoms of systemic toxicity include central nervous system (CNS) effects (e.g., dizziness, drowsiness, blurred vision, tremors, convulsions) and cardiovascular effects (e.g., bradycardia, hypotension, cardiac arrest). Management is supportive, involving airway management, anticonvulsants for seizures, and vasopressors for hypotension.
Pregnancy & Lactation
Pregnancy Category B. Lidocaine can be used during pregnancy if clearly needed. Minimal systemic absorption from topical use generally poses low risk. Excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to lidocaine or other amide-type local anesthetics.
- Application to large areas of broken or severely traumatized skin, as this increases the risk of systemic absorption and toxicity.
Drug Interactions
Other Local Anesthetics
Concurrent use may lead to additive systemic effects, increasing the risk of toxicity.
Antiarrhythmic Drugs (e.g., Mexiletine, Amiodarone)
Caution with concomitant use, especially if significant systemic absorption of lidocaine occurs, due to potential for additive cardiac effects.
Storage
Store below 25°C. Protect from light and moisture. Do not freeze. Keep out of sight and reach of children.
Overdose
Systemic overdose is rare with proper topical application. Symptoms of systemic toxicity include central nervous system (CNS) effects (e.g., dizziness, drowsiness, blurred vision, tremors, convulsions) and cardiovascular effects (e.g., bradycardia, hypotension, cardiac arrest). Management is supportive, involving airway management, anticonvulsants for seizures, and vasopressors for hypotension.
Pregnancy & Lactation
Pregnancy Category B. Lidocaine can be used during pregnancy if clearly needed. Minimal systemic absorption from topical use generally poses low risk. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Lidocaine's efficacy and safety for topical anesthesia are well-established through extensive clinical use and historical trials over many decades. Specific trials may exist for novel formulations or indications.
Lab Monitoring
- No routine lab monitoring is required for topical lidocaine gel when used as directed.
Doctor Notes
- Educate patients on proper application technique and maximum daily dose to minimize systemic absorption risk.
- Advise caution when applying to areas with compromised skin barrier, in pediatric patients, or in patients with hepatic/renal impairment, where systemic toxicity risk might be higher.
- Monitor for signs of CNS or cardiovascular toxicity if large areas or prolonged use is necessary.
Patient Guidelines
- For external use only. Avoid contact with eyes.
- Do not apply to large areas of broken, abraded, or inflamed skin without medical advice.
- Wash hands thoroughly before and after applying the gel.
- Keep out of reach of children and pets.
Missed Dose Advice
Apply the gel when you remember if relief is still needed. Do not apply a double dose to make up for a missed one.
Driving Precautions
Topical lidocaine gel is unlikely to affect the ability to drive or operate machinery. However, if systemic absorption leads to dizziness or drowsiness, avoid such activities.
Lifestyle Advice
- Maintain good hygiene in the affected area.
- Consult a doctor if pain or discomfort persists or worsens after use.
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Global Brand Names
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