Z-Sil
Generic Name
Z-Sil 10 mg/5 ml Syrup
Manufacturer
PharmaCo Bangladesh Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| z sil 10 mg syrup | ৳ 25.17 | N/A |
Description
Overview of the medicine
Z-Sil 10 mg/5 ml Syrup is an antihistamine used for symptomatic relief of allergic conditions such as seasonal allergic rhinitis, perennial allergic rhinitis, and chronic idiopathic urticaria. It helps to alleviate symptoms like sneezing, runny nose, itchy eyes, and skin rashes.
Uses & Indications
Dosage
Adults
Adults and adolescents 12 years and over: 10 mg (10 ml) once daily.
Elderly
No dosage adjustment is generally required for elderly patients with normal renal function. For elderly with impaired renal function, dosage should be adjusted as per physician's advice.
Renal_impairment
Patients with moderate to severe renal impairment (creatinine clearance < 30 ml/min) should consult their doctor for dosage adjustment. Typically, 5 mg (5 ml) once daily or alternate day dosing is recommended.
How to Take
Take Z-Sil syrup orally, with or without food. Use the provided measuring spoon or cup to ensure accurate dosing. Do not exceed the recommended dose.
Mechanism of Action
Z-Sil acts as a selective H1-receptor antagonist. It effectively blocks the action of histamine, a natural substance released by the body during an allergic reaction, thereby preventing the symptoms of allergy.
Pharmacokinetics
Onset
Within 30-60 minutes after oral dose.
Excretion
Primarily excreted in the urine, with a small portion eliminated in the feces. Renal impairment can significantly prolong its elimination half-life.
Half life
Approximately 8-12 hours in adults, may be longer in children and elderly patients.
Absorption
Rapidly absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are usually reached within 1-2 hours.
Metabolism
Undergoes minimal hepatic metabolism. The majority of the drug is excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to Z-Sil, hydroxyzine, or any piperazine derivatives.
- Patients with severe renal impairment (creatinine clearance < 10 ml/min).
Drug Interactions
Theophylline
A small decrease in Z-Sil clearance has been observed with concurrent theophylline administration (400 mg/day).
Alcohol and CNS Depressants
Concurrent use may enhance CNS depression and impair alertness.
Storage
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose may include drowsiness, agitation, headache, tachycardia, and urinary retention. In case of an overdose, seek immediate medical attention. Management is primarily symptomatic and supportive; there is no specific antidote. Gastric lavage may be considered if recent ingestion.
Pregnancy & Lactation
Consult your doctor before using Z-Sil syrup if you are pregnant, planning to become pregnant, or breastfeeding. While studies have not shown significant harm, use only if clearly needed and the potential benefit outweighs the potential risk to the fetus or infant.
Side Effects
Contraindications
- Known hypersensitivity to Z-Sil, hydroxyzine, or any piperazine derivatives.
- Patients with severe renal impairment (creatinine clearance < 10 ml/min).
Drug Interactions
Theophylline
A small decrease in Z-Sil clearance has been observed with concurrent theophylline administration (400 mg/day).
Alcohol and CNS Depressants
Concurrent use may enhance CNS depression and impair alertness.
Storage
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose may include drowsiness, agitation, headache, tachycardia, and urinary retention. In case of an overdose, seek immediate medical attention. Management is primarily symptomatic and supportive; there is no specific antidote. Gastric lavage may be considered if recent ingestion.
Pregnancy & Lactation
Consult your doctor before using Z-Sil syrup if you are pregnant, planning to become pregnant, or breastfeeding. While studies have not shown significant harm, use only if clearly needed and the potential benefit outweighs the potential risk to the fetus or infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture. Once opened, consume within 3 months.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Pending
Clinical Trials
Z-Sil has undergone extensive Phase III clinical trials demonstrating its efficacy and safety in treating allergic rhinitis and chronic idiopathic urticaria. These trials involved a large cohort of patients and showed a favorable risk-benefit profile.
Lab Monitoring
- Routine lab monitoring is generally not required for Z-Sil syrup. However, liver and renal function tests may be considered in patients with pre-existing hepatic or renal impairment.
Doctor Notes
- Counsel patients on potential drowsiness and advise caution with driving or operating machinery.
- Evaluate renal function, especially in elderly patients, and adjust dosage accordingly.
- Advise against concomitant use of alcohol or other CNS depressants.
- Monitor for rare but serious adverse effects such as hepatic dysfunction or severe allergic reactions.
Patient Guidelines
- Always follow your doctor's instructions regarding dosage and duration of treatment.
- Do not exceed the recommended dose, as it may increase the risk of side effects.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Avoid alcohol while taking this medicine, as it may enhance drowsiness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Z-Sil syrup may cause drowsiness or dizziness in some individuals. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid known allergens to prevent allergic reactions.
- Stay hydrated by drinking plenty of fluids.
- If symptoms persist or worsen, consult your doctor.
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Global Brand Names
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