Zadifen
Generic Name
Ketotifen
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zadifen 1 mg syrup | ৳ 50.00 | N/A |
Description
Overview of the medicine
Zadifen 1 mg Syrup contains Ketotifen, an oral antiasthmatic agent primarily used for the prophylactic treatment of bronchial asthma, allergic bronchitis, hay fever, and other allergic conditions. It also possesses antihistaminic properties.
Uses & Indications
Dosage
Adults
1 mg (5 ml syrup) twice daily, with meals, in the morning and evening. In resistant cases, the dose may be increased to 2 mg (10 ml syrup) twice daily.
Elderly
No special dosage recommendations for the elderly, generally similar to adult dosage. Caution should be exercised if co-morbidities or concomitant medications are present.
Renal_impairment
No specific dosage adjustment is generally required, but caution is advised in severe renal impairment.
How to Take
Zadifen syrup should be taken orally, with meals (morning and evening), to minimize potential gastrointestinal discomfort.
Mechanism of Action
Ketotifen acts as a mast cell stabilizer, preventing the release of histamine and other inflammatory mediators (e.g., leukotrienes) from mast cells. It also exerts H1-antihistamine activity, blocking histamine receptors and reducing allergic symptoms.
Pharmacokinetics
Onset
Antihistaminic effects may be noted within hours; however, the full prophylactic effect in asthma may take several weeks (e.g., 2 to 4 weeks) of continuous treatment.
Excretion
Approximately 60-70% is excreted in the urine (mostly as metabolites) and a smaller proportion in the feces.
Half life
Biphasic elimination. The elimination half-life of the parent drug is approximately 3-5 hours, with some metabolites having a longer half-life (up to 21 hours).
Absorption
Rapidly absorbed from the gastrointestinal tract. Bioavailability is approximately 50% due to significant first-pass metabolism. Peak plasma concentrations are achieved within 2-4 hours.
Metabolism
Extensively metabolized in the liver, primarily via N-glucuronidation to an inactive metabolite.
Side Effects
Contraindications
- •Hypersensitivity to Ketotifen or any excipients
- •Epilepsy or a history of seizures
Drug Interactions
CNS Depressants
Concomitant use with CNS depressants (e.g., hypnotics, sedatives, alcohol) may enhance their sedative effects.
Oral Antidiabetics
Rare, reversible decrease in platelet count has been observed in a few patients also taking oral antidiabetics; therefore, concomitant use is not recommended.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, confusion, disorientation, tachycardia, CNS stimulation (especially in children), and possibly coma. Management involves gastric lavage, followed by symptomatic and supportive treatment. Physostigmine may be considered for severe anticholinergic symptoms.
Pregnancy & Lactation
Pregnancy Category C. Ketotifen should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. It is excreted into breast milk, so breast-feeding is not recommended during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture when stored correctly.
Availability
Pharmacies
Approval Status
Approved
Patent Status
Generic
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