Zedex
Generic Name
Rabeprazole
Manufacturer
ACME Laboratories
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zedex 20 mg tablet | ৳ 1.50 | ৳ 45.00 |
Description
Overview of the medicine
Rabeprazole is a proton pump inhibitor used to treat conditions involving excessive stomach acid, such as heartburn, acid reflux, gastroesophageal reflux disease (GERD), and peptic ulcers.
Uses & Indications
Dosage
Adults
For GERD: 20 mg once daily for 4-8 weeks. For duodenal ulcer: 20 mg once daily for 4 weeks. For H. pylori eradication: 20 mg twice daily with two antibiotics for 7 days.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is generally required for patients with mild to moderate renal impairment. Caution is advised in severe impairment.
How to Take
Zedex-20mg tablet should be swallowed whole, preferably in the morning before a meal. Do not crush, chew, or split the tablet.
Mechanism of Action
Rabeprazole irreversibly binds to and inhibits the H+/K+-ATPase pump (proton pump) in gastric parietal cells, leading to a significant reduction in gastric acid secretion.
Pharmacokinetics
Onset
Acid inhibitory effect starts within 1 hour, with maximal effect seen within 2-4 hours.
Excretion
Approximately 90% of a dose is excreted via urine (as metabolites) and the remainder in feces.
Half life
Plasma elimination half-life is 1-2 hours, but the duration of acid suppression is much longer due to irreversible binding.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations occurring within 2-5 hours. Bioavailability is approximately 52% after the first dose.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19 and CYP3A4 enzymes. Metabolites are mostly inactive.
Side Effects
Contraindications
- Hypersensitivity to rabeprazole, substituted benzimidazoles, or any component of the formulation.
- Pregnancy and lactation (unless clearly indicated by a physician).
Drug Interactions
Warfarin
There have been reports of increased INR and prothrombin time in patients receiving concomitant PPIs and warfarin, which may lead to abnormal bleeding.
Methotrexate
Concomitant use with high-dose methotrexate may increase and prolong serum levels of methotrexate and its metabolite, potentially leading to toxicity.
Drugs dependent on gastric pH for absorption (e.g., Ketoconazole, Itraconazole, Atazanavir, Iron salts)
Rabeprazole can reduce the absorption of these drugs due to its acid-suppressing effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Experience with rabeprazole overdose is limited. Symptomatic and supportive treatment should be given in case of overdose. Rabeprazole is not readily dialyzable.
Pregnancy & Lactation
Rabeprazole should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Exercise caution when administering to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to rabeprazole, substituted benzimidazoles, or any component of the formulation.
- Pregnancy and lactation (unless clearly indicated by a physician).
Drug Interactions
Warfarin
There have been reports of increased INR and prothrombin time in patients receiving concomitant PPIs and warfarin, which may lead to abnormal bleeding.
Methotrexate
Concomitant use with high-dose methotrexate may increase and prolong serum levels of methotrexate and its metabolite, potentially leading to toxicity.
Drugs dependent on gastric pH for absorption (e.g., Ketoconazole, Itraconazole, Atazanavir, Iron salts)
Rabeprazole can reduce the absorption of these drugs due to its acid-suppressing effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Experience with rabeprazole overdose is limited. Symptomatic and supportive treatment should be given in case of overdose. Rabeprazole is not readily dialyzable.
Pregnancy & Lactation
Rabeprazole should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Exercise caution when administering to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture. Refer to the packaging for the exact expiry date.
Availability
Pharmacies
Approval Status
Approved
Patent Status
Expired for generic
WHO Essential Medicine
YesClinical Trials
Rabeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of GERD, peptic ulcers, and other acid-related disorders. Studies have shown rapid onset of action and sustained acid suppression.
Lab Monitoring
- Generally not required for routine use. For long-term use (over 3 months), periodic monitoring of serum magnesium levels may be considered, especially in patients taking other medications that can cause hypomagnesemia.
Doctor Notes
- Educate patients on the proper administration of PPIs and the importance of adhering to the prescribed duration of treatment.
- Consider assessing Vitamin B12 levels in patients on long-term PPI therapy, as absorption may be affected.
- Be aware of potential drug interactions, especially with warfarin and methotrexate. Monitor patients accordingly.
Patient Guidelines
- Take Zedex-20mg exactly as prescribed by your doctor. Do not alter the dose or stop treatment without consulting your doctor.
- Swallow the tablet whole; do not crush, chew, or break it.
- If you experience any new or worsening symptoms, consult your doctor immediately.
- Long-term use of PPIs may increase the risk of osteoporosis-related fractures of the hip, wrist, or spine, and C. difficile associated diarrhea.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Rabeprazole may cause dizziness or visual disturbances in some patients. If these symptoms occur, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods like spicy foods, fatty foods, chocolate, caffeine, and acidic beverages if they worsen your symptoms.
- Eat smaller, more frequent meals. Avoid eating close to bedtime.
- Elevate the head of your bed to help reduce nighttime GERD symptoms.
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Global Brand Names
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