Zeefol-M
Generic Name
Zeefol-M-47-mg-tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zeefol m 47 mg tablet | ৳ 3.50 | ৳ 35.00 |
Description
Overview of the medicine
Zeefol-M 47 mg tablet is a nutritional supplement containing a combination of Folic Acid (Vitamin B9), Methylcobalamin (Vitamin B12), and Pyridoxine Hydrochloride (Vitamin B6). It is primarily used to prevent and treat vitamin deficiencies, especially in conditions like peripheral neuropathy, megaloblastic anemia, and during pregnancy or lactation.
Uses & Indications
Dosage
Adults
Typically one tablet once daily, or as directed by a physician.
Elderly
Same as adults, no specific dosage adjustment usually needed.
Renal_impairment
No specific dosage adjustment is usually required, but consult a physician for severe cases.
How to Take
Take orally, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Folic Acid is essential for nucleotide biosynthesis and homocysteine remethylation. Methylcobalamin, an active form of Vitamin B12, is crucial for nerve tissue integrity, red blood cell formation, and DNA synthesis. Pyridoxine (Vitamin B6) acts as a coenzyme in various metabolic pathways, including amino acid metabolism and neurotransmitter synthesis.
Pharmacokinetics
Onset
Gradual, effects usually seen over weeks.
Excretion
Primarily renal, with some biliary excretion for Folic Acid.
Half life
Varies for each component (Folic Acid: 3-4 hours; Pyridoxine: 15-20 days for plasma pyridoxal phosphate; Methylcobalamin: variable, long tissue retention).
Absorption
Readily absorbed from the gastrointestinal tract.
Metabolism
Primarily hepatic (for Folic Acid and Pyridoxine). Methylcobalamin is the active form and undergoes minimal metabolism.
Side Effects
Contraindications
- Hypersensitivity to any component of the tablet
- Leber's disease or other optic nerve atrophy (due to Vitamin B12 content)
Drug Interactions
Levodopa
Pyridoxine may reduce the effectiveness of levodopa (unless combined with a decarboxylase inhibitor).
Phenytoin
Folic acid may decrease phenytoin levels.
Methotrexate
Folic acid can interfere with methotrexate action.
Chloramphenicol
May reduce the therapeutic effect of Vitamin B12.
H2 receptor antagonists & Proton Pump Inhibitors
May reduce Vitamin B12 absorption.
Storage
Store below 30°C, in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose is unlikely with typical doses, as B vitamins are water-soluble and excess is excreted. In cases of massive overdose, supportive and symptomatic treatment should be administered.
Pregnancy & Lactation
Generally considered safe and often recommended, especially Folic Acid, during pregnancy and lactation to meet increased nutritional demands. Consult a physician.
Side Effects
Contraindications
- Hypersensitivity to any component of the tablet
- Leber's disease or other optic nerve atrophy (due to Vitamin B12 content)
Drug Interactions
Levodopa
Pyridoxine may reduce the effectiveness of levodopa (unless combined with a decarboxylase inhibitor).
Phenytoin
Folic acid may decrease phenytoin levels.
Methotrexate
Folic acid can interfere with methotrexate action.
Chloramphenicol
May reduce the therapeutic effect of Vitamin B12.
H2 receptor antagonists & Proton Pump Inhibitors
May reduce Vitamin B12 absorption.
Storage
Store below 30°C, in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose is unlikely with typical doses, as B vitamins are water-soluble and excess is excreted. In cases of massive overdose, supportive and symptomatic treatment should be administered.
Pregnancy & Lactation
Generally considered safe and often recommended, especially Folic Acid, during pregnancy and lactation to meet increased nutritional demands. Consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date
Availability
Pharmacies, drugstores
Approval Status
Approved by relevant health authorities (e.g., DGDA)
Patent Status
Off-patent
Clinical Trials
Generally not applicable for this standard vitamin combination, but individual components have extensive clinical data.
Lab Monitoring
- Generally not required for routine supplementation.
- May be indicated for monitoring specific vitamin deficiency levels in certain conditions.
Doctor Notes
- Emphasize the importance of B vitamins in nerve health and red blood cell formation, particularly in patients with diabetes or B12/folate deficiency.
- Advise patients on lifestyle modifications to enhance vitamin absorption.
Patient Guidelines
- Take the tablet exactly as prescribed or as per package instructions.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications and supplements you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Zeefol-M is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in fruits, vegetables, and whole grains.
- Avoid excessive alcohol consumption as it may interfere with vitamin absorption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.