Zemicef-Max
Generic Name
Cefixime 100 mg Pediatric Drop
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zemicef max 100 mg pediatric drop | ৳ 250.00 | N/A |
Description
Overview of the medicine
Zemicef-Max 100 mg Pediatric Drop contains Cefixime, a third-generation cephalosporin antibiotic, used to treat a wide range of bacterial infections in children.
Uses & Indications
Dosage
Adults
Not applicable for this pediatric formulation.
Elderly
Not applicable for this pediatric formulation.
Renal_impairment
Dosage adjustment is required for children with renal impairment; consult a physician for specific guidance.
How to Take
Administer orally, with or without food. Shake the bottle well before each use. Use the provided calibrated dropper for accurate dosing. Can be mixed with a small amount of water or juice if needed.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis, leading to cell lysis and bacterial death. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved within 2 to 6 hours after administration.
Excretion
Approximately 50% of the absorbed dose is excreted unchanged in the urine over 24 hours. Some biliary excretion also occurs.
Half life
Plasma half-life averages 3 to 4 hours.
Absorption
Approximately 40-50% orally absorbed. Food can slightly delay absorption but does not significantly alter its extent.
Metabolism
Cefixime is not significantly metabolized in vivo.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, other cephalosporins, or to penicillin antibiotics.
Drug Interactions
Warfarin
Concurrent use with warfarin may increase prothrombin time (PT) and INR, leading to an increased risk of bleeding. Close monitoring is recommended.
Carbamazepine
Increased carbamazepine levels have been reported when co-administered with cefixime.
Storage
Store the dry powder below 30°C, away from moisture and direct light. Once reconstituted, store the suspension in a refrigerator (2-8°C) and do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Treatment is generally symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during lactation should be done with caution, and a physician should be consulted.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, other cephalosporins, or to penicillin antibiotics.
Drug Interactions
Warfarin
Concurrent use with warfarin may increase prothrombin time (PT) and INR, leading to an increased risk of bleeding. Close monitoring is recommended.
Carbamazepine
Increased carbamazepine levels have been reported when co-administered with cefixime.
Storage
Store the dry powder below 30°C, away from moisture and direct light. Once reconstituted, store the suspension in a refrigerator (2-8°C) and do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Treatment is generally symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during lactation should be done with caution, and a physician should be consulted.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Dry powder: 24-36 months from manufacturing date. Reconstituted suspension: 7-14 days when stored in a refrigerator (2-8°C).
Availability
Pharmacies and hospitals in Bangladesh
Approval Status
Approved by Directorate General of Drug Administration (DGDA), Bangladesh
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Cefixime is a well-established antibiotic with extensive clinical trial data supporting its efficacy and safety across various bacterial infections, particularly in pediatric populations.
Lab Monitoring
- Monitoring of renal function for prolonged therapy.
- Monitoring of INR for patients on warfarin.
Doctor Notes
- Emphasize patient compliance to complete the entire course of therapy to prevent bacterial resistance.
- Prescribe only for infections proven or strongly suspected to be caused by susceptible bacteria.
Patient Guidelines
- Complete the full course of medication as prescribed by your doctor, even if symptoms improve.
- Do not share this medicine with others.
- Shake the bottle well before each use and use the provided dropper for accurate measurement.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefixime generally does not impair the ability to drive or operate machinery. However, rare side effects like dizziness might occur, so caution is advised if affected.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Ensure a balanced diet for overall health during recovery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.