Zenestrim
Generic Name
zenestrim-1-cream
Manufacturer
PharmaCorp Inc.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
zenestrim 1 cream | ৳ 35.00 | N/A |
Description
Overview of the medicine
Zenestrim-1 Cream contains a potent corticosteroid used to treat various inflammatory skin conditions such as eczema, psoriasis, and dermatitis.
Uses & Indications
Dosage
Adults
Apply a thin film to the affected skin area once or twice daily, for up to 2-4 weeks. Do not exceed the prescribed duration.
Elderly
Same as adult dosage, but caution should be exercised with prolonged use due to potential for skin thinning and increased systemic absorption.
Renal_impairment
No specific dosage adjustment is typically needed for topical use, as systemic absorption is minimal.
How to Take
For external use only. Apply sparingly to the affected area and rub in gently. Do not apply to open wounds, broken skin, or large body areas. Avoid contact with eyes and mucous membranes. Wash hands thoroughly after application.
Mechanism of Action
It works by reducing inflammation, itching, and redness in the skin by suppressing the immune response and decreasing the production of inflammatory mediators.
Pharmacokinetics
Onset
Symptomatic relief can be observed within hours to days of initial application.
Excretion
Metabolites are primarily excreted in the urine.
Half life
Not readily measurable for topical application; systemically absorbed corticosteroids typically have short biological half-lives.
Absorption
Minimal systemic absorption through intact skin; increased with occlusive dressings, inflamed or damaged skin, and prolonged use.
Metabolism
Primarily metabolized in the liver for the small portion that is systemically absorbed.
Side Effects
Contraindications
- Hypersensitivity to Zenestrim or any component of the cream
- Untreated bacterial, fungal, or viral skin infections (e.g., herpes simplex, varicella)
- Tuberculosis of the skin
- Acne vulgaris
- Rosacea
- Perioral dermatitis
- Pruritus without inflammation
Drug Interactions
None significant for topical application
Systemic drug interactions are unlikely given the minimal systemic absorption. However, caution with other topical preparations to avoid irritation.
Storage
Store below 30°C in a dry place, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose with topical application is unlikely. Chronic overdose or misuse can lead to signs of hypercortisolism (Cushing's syndrome), adrenal suppression, or local adverse effects like skin atrophy. Treatment is symptomatic and supportive; gradual withdrawal if systemic effects are evident.
Pregnancy & Lactation
Use with caution during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus or infant. Avoid large areas or prolonged use. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to Zenestrim or any component of the cream
- Untreated bacterial, fungal, or viral skin infections (e.g., herpes simplex, varicella)
- Tuberculosis of the skin
- Acne vulgaris
- Rosacea
- Perioral dermatitis
- Pruritus without inflammation
Drug Interactions
None significant for topical application
Systemic drug interactions are unlikely given the minimal systemic absorption. However, caution with other topical preparations to avoid irritation.
Storage
Store below 30°C in a dry place, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose with topical application is unlikely. Chronic overdose or misuse can lead to signs of hypercortisolism (Cushing's syndrome), adrenal suppression, or local adverse effects like skin atrophy. Treatment is symptomatic and supportive; gradual withdrawal if systemic effects are evident.
Pregnancy & Lactation
Use with caution during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus or infant. Avoid large areas or prolonged use. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory bodies
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Clinical trials have demonstrated the efficacy and safety of topical corticosteroids for treating various inflammatory dermatoses, consistent with the expected profile of Zenestrim-1 Cream.
Lab Monitoring
- Adrenal function tests (e.g., plasma cortisol levels) may be considered if extensive body surface area is treated for prolonged periods, especially in children.
Doctor Notes
- Emphasize to patients the importance of using Zenestrim-1 Cream for the shortest duration and lowest effective dose.
- Advise patients on proper application technique and to avoid occlusive dressings unless specifically instructed.
- Monitor for signs of local skin reactions, skin atrophy, or potential systemic absorption, especially in pediatric patients or when applied to large areas.
Patient Guidelines
- Use Zenestrim-1 Cream exactly as prescribed by your doctor.
- Do not apply more often or for longer than recommended.
- Avoid using on the face, groin, or underarms unless specifically directed by your doctor.
- Do not cover the treated area with bandages or other occlusive dressings unless advised.
- Wash your hands before and after applying the cream.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not apply a double dose.
Driving Precautions
Zenestrim-1 Cream is for topical use and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Keep the affected skin area clean and well-moisturized with a non-medicated emollient.
- Avoid known irritants or allergens that trigger your skin condition.
- Wear loose, breathable clothing over treated areas to prevent irritation and aid healing.
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Global Brand Names
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