Zerobac
Generic Name
Azithromycin 125 mg Suspension
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zerobac 125 mg suspension | ৳ 84.76 | N/A |
Description
Overview of the medicine
Zerobac 125 mg Suspension is an antibiotic used to treat a wide variety of bacterial infections in children. It belongs to the macrolide class of antibiotics and works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
Not applicable for 125 mg suspension (adults usually take higher strengths, e.g., 250 mg or 500 mg tablets/capsules)
Elderly
Not applicable for 125 mg suspension
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment; use with caution in severe impairment.
How to Take
Administer orally, with or without food. Shake the bottle well before each use. Use an oral syringe or measuring spoon for accurate dosing.
Mechanism of Action
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby blocking the translocation of peptides.
Pharmacokinetics
Onset
Within 2-3 hours
Excretion
Mainly excreted unchanged in bile; a small amount is excreted in urine.
Half life
Terminal half-life is 2-4 days, allowing for once-daily dosing.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%.
Metabolism
Primarily hepatic, but minimal metabolism in humans; N-demethylation is the main metabolic pathway.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Digoxin
Increased digoxin levels
Warfarin
Increased anticoagulant effect
Nelfinavir
Increased azithromycin concentration
Antacids (containing aluminum or magnesium)
Decreased azithromycin absorption (administer azithromycin at least 2 hours before or after antacids)
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children. After reconstitution, store at room temperature or refrigerated, depending on specific manufacturer instructions.
Overdose
Symptoms may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment is symptomatic and supportive. Gastric lavage and general supportive measures may be indicated.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Digoxin
Increased digoxin levels
Warfarin
Increased anticoagulant effect
Nelfinavir
Increased azithromycin concentration
Antacids (containing aluminum or magnesium)
Decreased azithromycin absorption (administer azithromycin at least 2 hours before or after antacids)
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children. After reconstitution, store at room temperature or refrigerated, depending on specific manufacturer instructions.
Overdose
Symptoms may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment is symptomatic and supportive. Gastric lavage and general supportive measures may be indicated.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months (unopened); 5-10 days after reconstitution.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available (Patent expired for Azithromycin)
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established Azithromycin's efficacy and safety for various bacterial infections, particularly in respiratory tract infections and otitis media in pediatric populations.
Lab Monitoring
- Liver function tests (in patients with pre-existing hepatic impairment)
- Renal function tests (in severe renal impairment)
- ECG (in patients with risk factors for QT prolongation)
Doctor Notes
- Educate parents on proper reconstitution and administration techniques.
- Stress importance of completing the full course.
- Advise on potential for GI upset and to report severe diarrhea.
Patient Guidelines
- Complete the full course of medication even if symptoms improve.
- Do not save medicine for future illnesses.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness in some individuals. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain good hydration.
- Avoid self-medication with other antibiotics.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.