Zerodol
Generic Name
Aceclofenac
Manufacturer
Ipca Laboratories Ltd.
Country
India
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zerodol 100 mg tablet | ৳ 3.01 | ৳ 30.10 |
Description
Overview of the medicine
Zerodol 100 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used for pain relief and inflammation associated with conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It works by blocking the production of certain chemical messengers that cause pain and inflammation.
Uses & Indications
Dosage
Adults
100 mg twice daily (every 12 hours).
Elderly
Usually no dose adjustment required, but caution is advised. Lowest effective dose for shortest duration.
Renal_impairment
No significant dose reduction needed for mild renal impairment, but caution in moderate to severe impairment. Start with reduced dose (e.g., 50 mg twice daily) and monitor.
How to Take
Orally, preferably with or after food to minimize gastrointestinal discomfort. Swallow the tablet whole with a glass of water. Do not chew or crush.
Mechanism of Action
Aceclofenac acts primarily by inhibiting prostaglandin synthesis through competitive inhibition of cyclooxygenase (COX) enzymes, COX-1 and COX-2. It exhibits greater selectivity for COX-2, leading to anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics
Onset
Analgesic effect within 30-60 minutes.
Excretion
Mainly excreted via urine (approx. 2/3) and feces (approx. 1/3) as metabolites.
Half life
Approximately 4 hours.
Absorption
Rapidly and completely absorbed after oral administration, peak plasma concentrations reached in 1.25 to 3 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C9, to 4'-hydroxyaceclofenac.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac or other NSAIDs (e.g., aspirin)
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Patients with a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Warfarin, other anticoagulants
Increased risk of bleeding.
Selective serotonin reuptake inhibitors (SSRIs)
Increased risk of gastrointestinal bleeding.
Diuretics, ACE inhibitors, Angiotensin II receptor antagonists
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, epigastric pain, gastrointestinal bleeding, diarrhea, dizziness, disorientation, excitation, tinnitus, convulsions. In case of overdose, symptomatic and supportive treatment should be given. Gastric lavage and activated charcoal may be considered within one hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C in first two trimesters (risk cannot be ruled out). Contraindicated in the third trimester due to potential premature closure of the ductus arteriosus. Use during lactation is not recommended as aceclofenac may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by drug regulatory authorities in various countries (e.g., DGDA in Bangladesh, CDSCO in India).
Patent Status
Generally off-patent (generic available)
Clinical Trials
Numerous clinical trials have established the efficacy and safety of aceclofenac in various inflammatory and painful conditions, comparing it with other NSAIDs like diclofenac and ibuprofen.
Lab Monitoring
- Complete blood count (CBC)
- Liver function tests (LFTs)
- Renal function tests (RFTs)
- Stool for occult blood (especially in long-term use)
Doctor Notes
- Advise patients to take with food.
- Monitor renal and hepatic function, especially in elderly or long-term users.
- Caution in patients with a history of GI issues or cardiovascular risk factors.
- Educate on symptoms of GI bleeding and cardiovascular events.
Patient Guidelines
- Take with food to reduce stomach upset.
- Do not exceed the recommended dose.
- Inform your doctor about all medications you are taking.
- Report any signs of gastrointestinal bleeding (e.g., black, tarry stools) immediately.
- Avoid alcohol consumption while on this medication.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or visual disturbances. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet and regular exercise, if suitable for your condition.
- Manage stress effectively.
- Avoid smoking.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.