Zeroflux
Generic Name
Fluoxacetin 500 mg Suspension
Manufacturer
PharmaInnovate Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zeroflux 500 mg suspension | ৳ 300.00 | N/A |
Description
Overview of the medicine
Zeroflux 500 mg Suspension is a novel broad-spectrum antibiotic indicated for the treatment of various bacterial infections. It works by inhibiting bacterial cell wall synthesis, leading to bacterial death. It is effective against a wide range of gram-positive and gram-negative bacteria.
Uses & Indications
Dosage
Adults
500 mg every 12 hours for 7-14 days, depending on the severity and type of infection.
Elderly
Similar to adult dosage; dose adjustment may be necessary based on renal function.
Renal_impairment
For severe renal impairment (creatinine clearance < 30 mL/min), the dosage should be reduced by half (e.g., 250 mg every 12 hours).
How to Take
Shake the suspension well before each use. Can be taken orally with or without food, but taking it with food may help reduce gastrointestinal discomfort.
Mechanism of Action
Fluoxacetin, the active ingredient in Zeroflux, inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This disruption of cell wall integrity leads to bacterial cell lysis and death, demonstrating its bactericidal activity.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Primarily via the kidneys through glomerular filtration and tubular secretion.
Half life
1.5 to 2.5 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract after oral administration. Bioavailability is approximately 80-85%. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Minimally metabolized in the liver; predominantly excreted as unchanged drug.
Side Effects
Contraindications
- Hypersensitivity to Fluoxacetin or any components of the formulation.
- History of severe allergic reactions to cephalosporins or penicillins.
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Close monitoring of INR is recommended.
Antacids (containing aluminum/magnesium)
May reduce the absorption of Fluoxacetin. Should be administered at least 2 hours apart.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze.
Overdose
In case of overdose, gastric lavage may be considered. Symptomatic and supportive treatment should be initiated. Hemodialysis may be effective in removing Fluoxacetin from the blood.
Pregnancy & Lactation
Pregnancy Category B. There are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Caution should be exercised when administered to a nursing mother as Fluoxacetin may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Fluoxacetin or any components of the formulation.
- History of severe allergic reactions to cephalosporins or penicillins.
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Close monitoring of INR is recommended.
Antacids (containing aluminum/magnesium)
May reduce the absorption of Fluoxacetin. Should be administered at least 2 hours apart.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze.
Overdose
In case of overdose, gastric lavage may be considered. Symptomatic and supportive treatment should be initiated. Hemodialysis may be effective in removing Fluoxacetin from the blood.
Pregnancy & Lactation
Pregnancy Category B. There are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Caution should be exercised when administered to a nursing mother as Fluoxacetin may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Under patent protection
Clinical Trials
Zeroflux has undergone comprehensive Phase 1, Phase 2, and Phase 3 clinical trials, demonstrating its efficacy and safety in treating various bacterial infections. The trials confirmed its broad-spectrum activity and favorable tolerability profile.
Lab Monitoring
- For prolonged therapy, periodic assessment of renal and hepatic function is recommended.
- Complete Blood Count (CBC) may be monitored.
Doctor Notes
- Educate patients on the importance of completing the full course of therapy to prevent the development of antibiotic resistance.
- Monitor patients for signs of allergic reactions, severe diarrhea (indicating possible C. difficile infection), or new infections (superinfections).
Patient Guidelines
- Complete the full course of medication as prescribed by your doctor, even if you feel better.
- Shake the bottle well before each use and use the provided measuring device for accurate dosing.
- Store the medicine out of reach of children.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Generally, Zeroflux does not impair the ability to drive or operate machinery. However, if you experience dizziness or fatigue, exercise caution.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids during the course of treatment.
- Ensure proper rest and a healthy diet to support recovery from infection.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.