Zest
Generic Name
Montelukast
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zest 6 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Zest 6 mg Tablet contains Montelukast, a leukotriene receptor antagonist used for the management of asthma and allergic rhinitis in children aged 6 to 14 years. It helps to reduce inflammation and symptoms associated with these conditions.
Uses & Indications
Dosage
Adults
Not typically used in adults for 6 mg strength; adult dosage is usually 10 mg once daily.
Elderly
Not applicable for 6 mg strength; elderly dosage is usually 10 mg once daily.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
Hepatic_impairment
No dosage adjustment is required for patients with mild to moderate hepatic impairment.
Pediatric (6-14 years)
One 6 mg chewable tablet daily, taken in the evening.
How to Take
Zest 6 mg tablet is a chewable tablet and should be chewed thoroughly before swallowing. It is usually taken once daily in the evening, with or without food. For asthma, it should be taken in the evening. For allergic rhinitis, the time of administration may be individualized.
Mechanism of Action
Montelukast selectively antagonizes the cysteinyl leukotriene 1 (CysLT1) receptor. Leukotrienes are potent inflammatory mediators released from various cells, including mast cells and eosinophils. By blocking CysLT1 receptors, Montelukast inhibits the bronchoconstriction and inflammatory effects of leukotrienes, thereby improving asthma symptoms and allergic rhinitis.
Pharmacokinetics
Onset
Within one day for asthma control.
Excretion
Primarily excreted in feces via bile (approximately 86%), with minimal renal excretion.
Half life
Approximately 2.7 to 5.5 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentration is achieved in 2-4 hours.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (CYP3A4, CYP2C9, CYP2A6).
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation.
- Not indicated for the treatment of acute asthma attacks.
Drug Interactions
Rifampicin
May decrease Montelukast plasma concentration due to induction of CYP3A4, CYP2C9, and CYP2A6.
Phenobarbital
May decrease Montelukast plasma concentration.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In cases of overdose, common adverse events included abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive; there is no specific antidote.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. It is unknown whether Montelukast is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation.
- Not indicated for the treatment of acute asthma attacks.
Drug Interactions
Rifampicin
May decrease Montelukast plasma concentration due to induction of CYP3A4, CYP2C9, and CYP2A6.
Phenobarbital
May decrease Montelukast plasma concentration.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In cases of overdose, common adverse events included abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive; there is no specific antidote.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. It is unknown whether Montelukast is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on storage conditions and specific formulation.
Availability
Available in pharmacies nationwide
Approval Status
Approved by national regulatory authorities (e.g., DGDA, FDA)
Patent Status
Expired
Clinical Trials
Montelukast has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in the treatment of asthma and allergic rhinitis across various age groups. Post-marketing surveillance continues to monitor for rare adverse events.
Lab Monitoring
- Routine laboratory monitoring is generally not required.
- Liver function tests may be considered in patients with pre-existing hepatic impairment or if symptoms of liver dysfunction develop.
Doctor Notes
- Emphasize to patients/caregivers the importance of reporting any new or worsening neuropsychiatric symptoms immediately.
- Montelukast is a prophylactic treatment; it is not for acute asthma exacerbations.
- Regularly assess adherence and efficacy, and re-evaluate the need for continued therapy.
Patient Guidelines
- Take Zest 6 mg daily as prescribed, even if you feel well.
- Do not stop taking this medicine abruptly without consulting your doctor.
- Inform your doctor about any unusual mood changes or behavioral symptoms.
- This medicine is not for immediate relief of acute asthma attacks.
Missed Dose Advice
If a dose is missed, take the next dose at the usual time. Do not take a double dose to make up for a missed dose.
Driving Precautions
Montelukast may cause dizziness or drowsiness in some individuals. Patients should be cautioned about driving or operating machinery until they are reasonably certain that Montelukast does not adversely affect their ability to perform such activities.
Lifestyle Advice
- Avoid known asthma triggers like pollen, dust mites, pet dander, and smoke.
- Maintain a healthy lifestyle with regular exercise (if appropriate) and a balanced diet.
- Discuss with your doctor about an asthma action plan.
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