Zif-A
Generic Name
Azithromycin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zif a 48 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Zif-A 48 mg tablet contains Azithromycin, a macrolide antibiotic used to treat various bacterial infections. The 48 mg strength is uncommon and typically requires specific medical guidance for its use.
Uses & Indications
Dosage
Adults
The 48 mg strength is highly atypical for standard adult systemic use of Azithromycin, which typically ranges from 250 mg to 1000 mg depending on the indication. Consult a physician for appropriate dosing guidance.
Elderly
No specific dose adjustment is generally required for elderly patients based on age alone. However, the 48 mg strength is not standard for this group, and a physician should be consulted.
Renal_impairment
No dosage adjustment necessary for mild to moderate renal impairment. Use with caution in severe renal impairment (creatinine clearance < 10 mL/min).
How to Take
Take orally, with or without food. To minimize gastrointestinal side effects, it may be taken with food. Do not take with aluminum or magnesium-containing antacids.
Mechanism of Action
Azithromycin works by binding to the 50S ribosomal subunit of susceptible microorganisms and, thus, inhibiting bacterial protein synthesis. This inhibition is bacteristatic, but at high concentrations, it may be bactericidal.
Pharmacokinetics
Onset
Within 2-3 hours
Excretion
Primarily unchanged in bile (approximately 50% of an oral dose); minor renal excretion (approximately 6% of an oral dose)
Half life
68 hours (terminal half-life)
Absorption
Rapidly absorbed after oral administration; bioavailability is approximately 37%. Peak plasma concentrations are reached within 2-3 hours.
Metabolism
Hepatic (via N-demethylation); limited first-pass metabolism
Side Effects
Contraindications
- •Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- •History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased serum digoxin concentrations. Monitor digoxin levels.
Warfarin
Increased anticoagulant effect. Monitor International Normalized Ratio (INR) closely.
Nelfinavir
Increased azithromycin concentrations, may necessitate dosage adjustment.
QT prolonging drugs
Increased risk of cardiac arrhythmias (e.g., antiarrhythmics, antipsychotics).
Antacids (aluminum/magnesium)
May reduce peak serum levels of azithromycin. Administer azithromycin at least 2 hours before or 4 hours after antacids.
Storage
Store below 30°C (86°F) in a dry place, protected from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment is symptomatic and supportive; gastric lavage and general supportive measures may be initiated as needed.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Azithromycin is excreted into breast milk; use with caution during breastfeeding, weighing potential risks and benefits.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date, depending on specific formulation and manufacturer.
Availability
Pharmacies nationwide
Approval Status
Approved (Generic)
Patent Status
Expired for generic Azithromycin
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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